Results 161 to 170 of about 2,302 (200)

Biotransformation of Cinobufagin by Cunninghamella elegans [PDF]

Journal of Antibiotics, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Li, Qiao, Yu-Zhi, Zhou, Xiu-Lan, Qi, Li-Hong, Lin, Huan, Chen, Li-Yan, Pang, Yue-Hu, Pei   +6 more
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Cyhalothrin biodegradation in Cunninghamella elegans

Environmental Science and Pollution Research, 2018
The insecticide λ-cyhalothrin was incubated with planktonic and biofilm cultures of the fungus Cunninghamella elegans. 19F nuclear magnetic resonance spectroscopy demonstrated that the compound was initially biosorbed to the biomass and more slowly degraded by the fungus. Furthermore, the presence of trifluoromethyl-containing metabolites was observed.
William Palmer-Brown, Paula Letícia de Melo Souza, Cormac D. Murphy   +2 more
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Biotransformation of Doxepin by Cunninghamella elegans

Drug Metabolism and Disposition, 1999
A filamentous fungus, Cunninghamella elegans ATCC 9245, was used as a microbial model of mammalian metabolism to biotransform doxepin, a tricyclic antidepressant drug. Doxepin is produced as an 85:15% mixture of the trans- (E) and cis- (Z) forms. After 96 h of incubation in Sabouraud dextrose broth, 28% of the drug was metabolized to 16 metabolites. No
J D, Moody, J P, Freeman, C E, Cerniglia
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Biotransformation of Mirtazapine by Cunninghamella Elegans

Drug Metabolism and Disposition, 2002
The fungus Cunninghamella elegans was used as a microbial model of mammalian metabolism to biotransform the tetracyclic antidepressant drug mirtazapine, which is manufactured as a racemic mixture of R(-)- and S(+)-enantiomers. In 168 h, C. elegans transformed 91% of the drug into the following seven metabolites: 8-hydroxymirtazapine, N-desmethyl-8 ...
Joanna D, Moody, James P, Freeman, Peter P, Fu, Carl E, Cerniglia   +3 more
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Fluorotelomer alcohols are efficiently biotransformed by Cunninghamella elegans

Environmental Science and Pollution Research, 2022
Cunninghamella elegans is a well-studied fungus that biotransforms a range of xenobiotics owing to impressive cytochrome P450 (CYP) activity. In this paper, we report the biotransformation of 6:2 fluorotelomer alcohol (6:2 FTOH) by the fungus, yielding a range of fluorinated products that were detectable by fluorine-19 nuclear magnetic resonance ...
Mohd Faheem Khan, Cormac D. Murphy
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Transformation of artemisinin by Cunninghamella elegans

Applied Microbiology and Biotechnology, 2004
Semi-synthetic derivatives of the anti-malarial drug artemisinin hold great promise in the search for an effective and economical treatment of chloroquine-resistant forms of malaria. Unfortunately, synthetic functionalization of the artemisinin skeleton is often tedious and/or impractical.
Parshikov, Igor A., Muraleedharan, K. M., Avery, Mitchell A., Williamson, John S.   +3 more
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Biotransformation of amitriptyline by Cunninghamella elegans.

Drug Metabolism and Disposition, 1995
A fungal biotransformation system as an in vitro model for mammalian drug metabolism was investigated. Amitriptyline, a widely used antidepressant, was effectively biotransformed within 72 hr by the filamentous fungus, Cunninghamella elegans. Eight major metabolites in HPLC elution order (11-hydroxyamitriptyline N-oxide, 11-hydroxynortriptyline, 11 ...
D, Zhang, F E, Evans, J P, Freeman, B, Duhart, C E, Cerniglia   +4 more
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Metabolism of quercetin by Cunninghamella elegans ATCC 9245

Journal of Bioscience and Bioengineering, 2011
Incubation of quercetin with Cunninghamella elegans ATCC 9245 yielded three metabolites, including quercetin 3-O-β-D-glucopyranoside, kaempferol 3-O-β-D-glucopyranoside and isorhamnetin 3-O-β-D-glucopyranoside. Glucosylation, O-methylation and dehydroxylation were involved in the process, among which dehydroxylation has never been found in ...
Jiachen, Zi, Jonathan, Valiente, Jia, Zeng, Jixun, Zhan   +3 more
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Sulfation of naringenin by Cunninghamella elegans

Phytochemistry, 2000
A new flavonoid sulfate, naringenin-7-sulfate, was obtained by fermentation of naringenin using the fungus Cunninghamella elegans NRRL 1392 in 23% yield. Structural elucidation of the metabolite was achieved using EIMS, UV, IR, 1D and 2D NMR spectroscopy beside acid and enzyme hydrolyses.
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Metabolism of Metolachlor by the Fungus Cunninghamella elegans

Archives of Environmental Contamination and Toxicology, 1997
The metabolism of metolachlor[2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-met hyl ethyl)acetamide]by the fungus Cunninghamella elegans ATCC 36112 was determined. Thesix metabolites identified comprised 81% of the total[14C]-metolachlor metabolized by C. elegans.
J V, Pothuluri, F E, Evans, D R, Doerge, M I, Churchwell, C E, Cerniglia   +4 more
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