Results 171 to 180 of about 2,302 (200)

Metabolism of Methoxychlor byCunninghamella elegansATCC36112

Journal of Agricultural and Food Chemistry, 2009
Methoxychlor is considered as pro-estrogen, while some of its metabolites are more potent endocrine disruptors than the parent insecticide. Major activation of methoxychlor is through cytochrome P450-catalyzed demethylation to bisphenol A-like metabolites.
Young Soo, Keum, Youn Hyung, Lee, Jeong-Han, Kim   +2 more
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Biotransformation of flumequine by the fungus Cunninghamella elegans

Chemosphere, 2007
The metabolism of the antibacterial fluoroquinolone drug flumequine by Cunninghamella elegans was investigated using cultures grown in Sabouraud dextrose broth with 308microM flumequine. The cultures were extracted with ethyl acetate; metabolites were separated by high-performance liquid chromatography and identified by mass spectrometry and proton ...
Anna J, Williams, Joanna, Deck, James P, Freeman, M, Paul Chiarelli, Michael D, Adjei, Thomas M, Heinze, John B, Sutherland   +6 more
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Hydroxylation of 10-Deoxoartemisinin byCunninghamella elegans

Journal of Natural Products, 2004
The microbial metabolism of 10-deoxoartemisinin (1), a derivative of the antimalarial drug artemisinin, was investigated. Various strains of fungi were investigated for their ability to transform 1. Of these microorganisms, only Cunninghamella elegans was capable of transforming 1 to 5beta-hydroxy-10-deoxoartemisinin (2), 4alpha-hydroxy-1,10 ...
Igor A, Parshikov, Kannoth M, Muraleedharan, Bruhaspathy, Miriyala, Mitchell A, Avery, John S, Williamson   +4 more
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Microbial transformation of dehydroandrographolide byCunninghamella elegans

Journal of Asian Natural Products Research, 2009
The biotransformation of dehydroandrographolide (1) by Cunninghamella elegans was performed and four transformed products were obtained. Based on their extensive spectral data, the structures of these metabolites were identified as 3-oxo-dehydroandrographolide (2), 3-oxo-2beta-hydroxy-dehydroandrographolide (3), 3-oxo-8beta,17alpha ...
Xiu-Lan, Xin, Xiao-Chi, Ma, Bao-Jing, Zhang, Dong-Hai, Su, Zhi-Ming, Wu, Xiao-Jie, Wang, Xiao-Yan, Li, Qi-Peng, Yuan   +7 more
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Transformation of jervine by Cunninghamella elegans ATCC 9245

Phytochemistry, 2000
Preparative-scale fermentation of the known C-nor-D-homosteroidal jerveratrum alkaloid jervine with Cunninghamella elegans (ATCC 9245) has resulted in the isolation of (-)-jervinone as the major metabolite. In addition, C. elegans ATCC 9245 was able to epimerize C-3 of jervine, producing 3-epi-jervine.
K A, El Sayed, A F, Halim, A M, Zaghloul, D C, Dunbar, J D, McChesney   +4 more
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Oxidation of phenothiazine and phenoxazine by Cunninghamella elegans

Xenobiotica, 2001
1. To determine the ability of fungi to metabolize sulphur- and oxygen-containing azaarenes, Cunninghamella elegans ATCC 9245 was grown in 125-ml flasks containing fluid Sabouraud medium. The cultures and controls were incubated at 28 degrees C with shaking and dosed with 16.7 mM phenothiazine or phenoxazine.
J B, Sutherland, J P, Freeman, T M, Heinze, J D, Moody, I A, Parshikov, A J, Williams, D, Zhang   +6 more
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Biotransformation of patchoulol by Cunninghamella echinulata var. elegans

Fitoterapia, 2016
Biocatalysis of patchoulol (PA) was performed by the fungus Cunninghamella echinulata var. elegans. Eight metabolites (1-8) including four new compounds were obtained, and their structures were elucidated as (5R,8S)-5,8 dihydroxypatchoulol (1), (5R*,9R*)-5,9 dihydroxypatchoulol (2), (6S*, 9S*)-6,9 dihydroxypatchoulol (3), and (4R*)-4 hydroxypatchoulol (
Fangfang Xu, Kangsheng Liao, Yuhong Liu, Zhenbiao Zhang, Dean Guo, Ziren Su, Bo Liu   +6 more
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Biotransformation of adrenosterone by filamentous fungus, Cunninghamella elegans

Steroids, 2007
Microbial transformation of adrenosterone (1) by suspended-cell cultures of the filamentous fungus Cunninghamella elegans resulted in the production of five metabolites 2-6, which were identified as 9alpha-hydroxyadrenosterone (2), 11-ketotestosterone (3), 6beta-hydroxyadrenosterone (4), 9alpha-hydroxy-11-ketotestosterone (5), and 6beta-hydroxy-11 ...
Muhammad Iqbal, Choudhary, Naik T, Khan, Syed G, Musharraf, Shazia, Anjum, , Atta-Ur-Rahman   +4 more
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Fungal biotransformation of mosapride by Cunninghamella elegans

Journal of Molecular Catalysis B: Enzymatic, 2009
Abstract The filamentous fungus, Cunninghamella elegans AS 3.156, was used as a microbial model of mammalian metabolism to transform mosapride, a selective 5-HT4-receptor agonist. The fungal metabolites of mosapride were separated and detected by ultra performance liquid chromatography–tandem mass spectrometric method. After incubation for 120 h, the
Xiao-Hong Sun, Feng Man, Li-Yan Pang, Gui-Hua Gao, Xiao-Qin Li, Xiu-Lan Qi, Fa-Mei Li   +6 more
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Oxidation of lynestrenol by the fungusCunninghamella elegans

Natural Product Research, 2010
Transformation of lynestrenol (19-nor-17alpha-pregn-4-en-20-yn-17beta-ol) (1) was carried out by incubation with Cunninghamella elegans to obtain 19-nor-17alpha-pregn-4-en-20-yn-3-one-10beta,17beta-diol (2), 19-nor-17alpha-pregn-4-en-20-yn-3-one-6beta,17beta-diol (3), and 19-nor-17alpha-pregn-4-en-20-yn-3beta,6beta,17beta-triol (4).
M, Iqbal Choudhary, M, Atif, Atta, Ur-Rahman   +2 more
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