Results 81 to 90 of about 68,623 (278)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Curate

open access: yesM/C Journal, 2015
We live in the “age of curation”, according to Eliot van Buskirk. In this issue of M/C Journal we bring together authors from diverse fields to explore what this ‘age’ looks, sounds and feels like. In so doing, the papers highlight both the ubiquitous and contested nature of curation.
Cathy Hope, Bethaney Turner
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Curatorial cultures : considering dynamic curatorial practice [PDF]

open access: yes
The practice of curating is live and temporal. It has shifted dramatically from its anonymous backstage origin within dusty museums to a role at the forefront of modern art, and is responsible for conjuring both a synergy and a dynamic that operates ...
Gaskill, Karen
core  

Library Technology Services at Boston University: an un-roadmap [PDF]

open access: yes, 2011
A working paper for discussionThis document attempts to identify user needs and expectations along with trends in scholarship, scholarly communication, and technologies that are the context in which decisions about library technologies are made.
Ammerman, Jack
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Metamorphoses: The Place of Moving Images

open access: yesThe Garage Journal, 2021
The migration of film from cinemas to art institutions engendered a series of metamorphoses. A metamorphosis of the medium, through the convergence of film and installation, produced the moving image.
Margherita Foresti
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Art after the Epistemic Crisis. On Nkule Mabaso and Nomusa Makhubu’s The Stronger We Become: The South African Pavilion (2019)

open access: yesThe Garage Journal, 2021
In this essay, the author discusses the reader that accompanied the South African Pavilion at the 58th Venice International Art Biennale—The Stronger We Become: The South African Pavilion (Natal Collective, Newcastle, South Africa, 2019; edited by Nkule
Serubiri Moses
doaj  

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