Results 21 to 30 of about 1,251,845 (238)
The Copyrights Chain in the Digital Curation Process
International Journal of Digital CurationThe internet era, open access movement, image sharing platforms, and mainly the rise of artificial intelligence (AI) emphasise the importance of providing moderated access and licences for the reuse of collections by memory institutes as a key step in ...
Keren Barner
doaj +1 more source
Connecting Data Publication to the Research Workflow: A Preliminary Analysis
International Journal of Digital Curation, 2017 The data curation community has long encouraged researchers to document collected research data during active stages of the research workflow, to provide robust metadata earlier, and support research data publication and preservation.
Sünje Dallmeier-Tiessen +5 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Frontiers in Environmental Science, 2019 The increased availability of publicly available data is, in many ways, changing our approach to conducting research. Not only are cloud-based information resources providing supplementary data to bolster traditional scientific activities (e.g., field ...
Linda C. Harwell +3 more
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Out of Our Heads! Four perspectives on the curation of an on-line exhibition of medically themed artwork by UK medical undergraduates [PDF]
Medical Education Online, 2010 The Medical School at Bristol University is noted for offering, and in some instances requiring, its students to work creatively with medical themes. Students, artists, educationalists and a web designer have worked to create an on-line exhibition of the
Trevor Thompson +3 more
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Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Endosomal H2O2 Molecules Act as Signaling Mediators in Akt/PKB Activation
AntioxidantsReceptor-mediated endocytosis (RME) is a commonly recognized receptor internalization process of receptor degradation or recycling. However, recent studies have supported that RME is closely related to signal propagation and amplification from the plasma
Sujin Park +3 more
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Guidelines for Data Acquisition, Quality and Curation for Observational Research Designs (DAQCORD)
Journal of Clinical and Translational Science, 2020 Background:High-quality data are critical to the entire scientific enterprise, yet the complexity and effort involved in data curation are vastly under-appreciated.
Ari Ercole +7 more
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Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source