Results 81 to 90 of about 41,846 (203)

Scale-Up Synthesis and In Vivo Anti-Tumor Activity of Curcumin Diethyl Disuccinate, an Ester Prodrug of Curcumin, in HepG2-Xenograft Mice

open access: yesPharmaceutics, 2019
Previously, we synthesized curcumin and a succinate ester prodrug of curcumin namely curcumin diethyl disuccinate (CurDD) in the lab scale, which yielded hundred milligrams to few grams of the compounds.
Chawanphat Muangnoi   +7 more
doaj   +1 more source

Comparative pharmacokinetic analysis of curcumin and curcumin O-glucuronide through curcumin nano-gel-based delivery system using liquid chromatogram tandem mass spectrometry

open access: yesPakistan Journal of Pharmaceutical Sciences
Background: Curcumin exhibits limited oral bioavailability owing to its poor solubility and rapid metabolism. Objectives: To develop a novel curcumin nano-gel (CNG) and evaluate its pharmacokinetics following oral and rectal administration.
Lue Hong   +5 more
doaj   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

open access: yesAngewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean   +3 more
wiley   +1 more source

Exploring the potential of curcumin-loaded PLGA nanoparticles for angiogenesis and antioxidant proficiency in zebrafish embryo (Danio rerio)

open access: yesFuture Journal of Pharmaceutical Sciences
Background Curcumin is an age old traditional medicine. Although curcumin has several advantages, its water solubility and bioavailability limit its use as a natural therapeutic agent.
Achinta Singha   +7 more
doaj   +1 more source

Curcumin inhibits the replication of enterovirus 71 in vitro

open access: yesActa Pharmaceutica Sinica B, 2014
Human enterovirus 71 (EV71) is the main causative pathogen of hand, foot, and mouth disease (HFMD) in children. The epidemic of HFMD has been a public health problem in Asia-Pacific region for decades, and no vaccine and effective antiviral medicine are ...
Ying Qin   +13 more
doaj   +1 more source

Fundamentals, Advances, and Applications of Electrospun Nanofibrous 3D Materials

open access: yesJournal of Applied Polymer Science, EarlyView.
Three‐dimensional electrospun nanofibrous systems offer unique properties and microenvironments. These properties are determined by the fabrication strategies employed and can be adjusted by the incorporation of functional additives to achieve multifunctionality for specific applications. The applications range from the biomedical to the environmental,
Rebecca Hengsbach   +4 more
wiley   +1 more source

Heat Stress in Quail: Impacts on Health and Productivity, and Mitigation Strategies

open access: yesAnimal Research and One Health, EarlyView.
Heat stress disrupts physiological homeostasis in quail, inducing oxidative stress, immune dysregulation, and metabolic imbalance, which impair growth, reproduction, product quality, and welfare. Integrating nutritional, environmental, and genetic–epigenetic strategies enhances thermotolerance, sustains productivity, and supports climate‐smart quail ...
T. A. Eletu   +6 more
wiley   +1 more source

Curcumin inhibits proliferation, migration, invasion and promotes apoptosis of retinoblastoma cell lines through modulation of miR-99a and JAK/STAT pathway

open access: yesBMC Cancer, 2018
Background Curcumin, a primary active ingredient extracted from the Curcuma longa, has been recently identified as a potential anti-tumor agent in multiple kinds of cancers.
Yaping Li   +4 more
doaj   +1 more source

Curcumin-Containing Diet Inhibits Diethylnitrosamine-Induced Murine Hepatocarcinogenesis

open access: yes, 2009
Curcumin has been widely used as a spice and coloring agent in foods. Recently, curcumin was found to possess chemopreventive effects against skin cancer, forestomach cancer, colon cancer and oral cancer in mice.
CHUANG, SHUANG-EN;KUO, MIN-LIANG;HSU, CHIH-HUNG;CHEN, CHI-LONG;LIN, JEN-KUN;LAI, GI-MING;HSIEH, CHANG-YAO;CHENG, ANN-LII   +1 more
core  

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

open access: yesBMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu   +9 more
wiley   +1 more source

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