Discovery of New Genes Involved in Curli Production by a Uropathogenic
mBio, 2018 Curli are bacterial surface-associated amyloid fibers that bind to the dye Congo red (CR) and facilitate uropathogenic Escherichia coli (UPEC) biofilm formation and protection against host innate defenses.
Nguyen Thi Khanh Nhu +12 more
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Systemic exposure to bacterial amyloid curli alters the gut mucosal immune response and the microbiome, exacerbating Salmonella-induced arthritis [PDF]
Gut Microbes, 2023 The Salmonella biofilm-associated amyloid protein, curli, is a dominant instigator of systemic inflammation and autoimmune responses following Salmonella infection.
Shingo Bessho +8 more
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Expression of curli by Escherichia coli O157:H7 strains isolated from patients during outbreaks is different from similar strains isolated from leafy green production environments [PDF]
Frontiers in Cellular and Infection Microbiology, 2016 We previously reported that the strains of Escherichia coli O157:H7 (EcO157) that survived longer in austere soil environment lacked expression of curli, a fitness trait linked with intestinal colonization.
Subbarao Venkata Ravva +2 more
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Structural analysis and architectural principles of the bacterial amyloid curli [PDF]
Nature Communications, 2023 Two decades have passed since the initial proposition that amyloids are not only (toxic) byproducts of an unintended aggregation cascade, but that they can also be produced by an organism to serve a defined biological function.
Mike Sleutel +3 more
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The Congo red derivative FSB binds to curli amyloid fibers and specifically stains curliated E. coli. [PDF]
PLoS ONE, 2018 The Congo red derivative (E,E)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy) styrylbenzene (FSB) specifically stains the functional amyloid curli in Escherichia coli biofilms.
Courtney Reichhardt, Lynette Cegelski
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PLoS Biology, 2020 Curli play critical roles in biofilm formation, host cell adhesion, and colonization of inert surfaces in many Enterobacteriaceae. In Escherichia coli, curli biogenesis requires 7 curli-specific gene (csg) products-CsgA through G-working in concert.
Manfeng Zhang +4 more
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Mutant and curli-producing E. coli enhance the disease phenotype in a hSOD1-G93A mouse model of ALS [PDF]
Scientific Reports, 2023 The gut microbiome is a potential non-genetic contributing factor for Amyotrophic Lateral Sclerosis. Differences in gut microbial communities have been detected between ALS subjects and healthy controls, including an increase in Escherichia coli in ALS ...
Zimple Kurlawala +9 more
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Transient binding facilitates super-resolution imaging of functional amyloid fibrils on living bacteria. [PDF]
Protein SciAbstract Curli, which are the major proteinaceous components of the Escherichia coli biofilm extracellular matrix, help protect cells against environmental stressors, including dehydration and antibiotics. Composed of the amyloid proteins CsgA and CsgB, curli self‐assemble as these protomers are secreted into the extracellular space.
Foust DJ +5 more
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The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid. [PDF]
Adv Sci (Weinh)Functional bacterial amyloids such as CsgA and FapC have been widely studied to understand the relationship between aggregation and function. The recently solved structure of FapC reveals a Greek‐key motif in which extensive hydrogen bonding and packing interactions formed by residues in conserved imperfect repeats stabilize a β‐solenoid core.
Peña-Díaz S +12 more
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Microbiome or Infections: Amyloid-Containing Biofilms as a Trigger for Complex Human Diseases
Frontiers in Immunology, 2021 The human microbiota is the community of microorganisms that live upon or within their human host. The microbiota consists of various microorganisms including bacteria, fungi, viruses, and archaea; the gut microbiota is comprised mostly of bacteria. Many
Amanda L. Miller +3 more
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