Results 81 to 90 of about 7,656,833 (303)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus [v1; ref status: indexed, http://f1000r.es/1d0]

F1000Research, 2013
The LIM-homeodomain (LIM-HD) family of transcription factors is well known for its functions during several developmental processes including cell fate specification, cell migration and axon guidance, and its members play fundamental roles in hippocampal
Vanisha Lakhina, Lakshmi Subramanian, Dhananjay Huilgol, Ashwin S Shetty, Vidita A. Vaidya, Shubha Tole   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Genetic mapping of deoxynivalenol and fusarium damaged kernel resistance in an adapted durum wheat population

BMC Plant Biology
Background Fusarium head blight (FHB) infection results in Fusarium damaged kernels (FDK) and deoxynivalenol (DON) contamination that are downgrading factors at the Canadian elevators. Durum wheat (Triticum turgidum L. var.
Samia Berraies, Yuefeng Ruan, Ron Knox, Ron DePauw, Firdissa Bokore, Richard Cuthbert, Barbara Blackwell, Maria Antonia Henriquez, David Konkin, Bianyun Yu, Curtis Pozniak, Brad Meyer   +11 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Spiral nematodes, soil microbiome and micronutrients increase chickpea drought susceptibility but do not induce symptoms of the emerging health issue

Scientific Reports
In 2019, an emerging health issue was noted in chickpea in Saskatchewan, Canada. Symptoms included apical wilting, branch chlorosis and necrosis. The causes remain unclear. In 2023 these symptoms appeared on one side (“unhealthy”, UH), but not the other (
Victoria A. Marchesini, Jennifer Town, Mario Tenuta, Fernanda Gouvea Pereira, Lana Shaw, Shaun Sharpe, Jeff Schoenau, Michelle Hubbard   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Mapping novel yellow and leaf rust loci and predicting resistance in cross derived Canadian durum wheat

The Plant Genome
Durum wheat (Triticum turgidum ssp. durum) suffers substantial yield losses from yellow rust (Puccinia striiformis) and leaf rust (Puccinia triticina).
Juan Menor de Gaspar, Alejandro Domínguez Rondón, Julián García‐Abadillo, Ron Knox, Firdissa E. Bokore, Kerry Boyle, Karim Ammar, Julio Huerta‐Espino, Samia Berraies, Brad Meyer, Wentao Zhang, Richard D. Cuthbert, Fobert Pierre, Yuefeng Ruan, Julio Isidro y Sánchez   +14 more
doaj   +1 more source