Results 171 to 180 of about 8,721,544 (291)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Multi-Modal Joint Pulsed Eddy Current Sensor Signal Denoising Method Integrating Inductive Disturbance Mechanism. [PDF]

Sensors (Basel)
Zuo Y, Hu G, Gan F, Zeng Z, Lin Z, Wang X, Xu R, Wen L, Hu S, Le H, Wu R, Wang J.   +11 more
europepmc   +1 more source

Eddy Current Sensor System for Tilting Independent In-Process Measurement of Magnetic Anisotropy. [PDF]

Sensors (Basel), 2021
Wendler F, Munjal R, Waqas M, Laue R, Härtel S, Awiszus B, Kanoun O.   +6 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Online Inductance Monitoring Based on Dynamic Characteristics and ESR Effect Compensation for Buck Converter Without Current Sensor. [PDF]

Sensors (Basel)
Chen C, Wang L, Wang W, Min R, Tong Q.
europepmc   +1 more source

Evaluation of Coating Thickness Using Lift-Off Insensitivity of Eddy Current Sensor. [PDF]

Sensors (Basel), 2021
Meng X, Lu M, Lu M, Yin W, Bennecer A, Kirk KJ.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

High-Precision Tunneling Magnetoresistance (TMR) Current Sensor for Weak Current Measurement in Smart Grid Applications. [PDF]

Micromachines (Basel)
Xu Y, Jin Z, Chen J.
europepmc   +1 more source

Parameter Determination and Ion Current Improvement of the Ion Current Sensor Used for Flame Monitoring. [PDF]

Sensors (Basel), 2021
Xu H, Fan W, Feng J, Yan P, Qi S, Zhang R.   +5 more
europepmc   +1 more source