Results 101 to 110 of about 286,510 (260)

Ripple‐Free Input Current Quadratic Converter Based on Watkin–Johnson Topology

open access: yesIET Power Electronics
This article proposes a power electronics converter capable of providing high voltage gain while keeping a high‐quality input current ripple operating with low duty cycle. The technique for achieving the zero input current ripple at a selected duty cycle
Brenda Lizeth Reyes‐García   +5 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Improvement of Direct Torque Control for Induction Motor with Type-2 Fuzzy

open access: yesApplied Sciences
Direct Torque Control (DTC) for induction motors (IMs) is an advanced method derived from Field-Oriented Control (FOC). In DTC, a voltage source inverter (VSI) is employed to directly regulate the stator flux linkage and electromagnetic torque through ...
Vinh Quan Nguyen   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Modeling, Analysis and Advanced Control of Voltage- and Current-Source Converters in Renewable Energy-Based Active Distribution Systems [PDF]

open access: yes, 2016
This thesis addresses the integration of renewable energy resources into the grid-connected and isolated distribution systems using voltage- and current-source converters.
Radwan, Amr A A
core   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

An 'active' passive-filter topology for low power DC/AC inverters [PDF]

open access: yes, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis presents a new output passive filter for voltage source inverter applications which is based on a shunt connected single tuned filter topology ...
Arman, Mahmoud Fayez
core  

Choosing an appropriate probiotic product for your patient: An evidence-based practical guide.

open access: yesPLoS ONE, 2018
IntroductionClinicians and patients face a daunting task when choosing the most appropriate probiotic for their specific needs. Available preparations encompass a diverse and continuously expanding product base, with most available products lacking ...
Jason C Sniffen   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

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