Results 111 to 120 of about 4,494,023 (283)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Identification of type of threading dislocation causing reverse leakage in GaN p-n junctions after continuous forward current stress. [PDF]

Sci Rep, 2022
Narita T, Kanechika M, Kojima J, Watanabe H, Kondo T, Uesugi T, Yamaguchi S, Kimoto Y, Tomita K, Nagasato Y, Ikeda S, Kosaki M, Oka T, Suda J.   +13 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Optimising sediment resuspension processes for improved modelling of solid waste in coastal aquaculture

Applied Ocean Research
Modelling sediment resuspension in shallow and dynamic coastal marine environments requires a quantification of the combined shear stresses from waves and currents acting on the seabed.
Jiaqi Zong, Scott Hadley
doaj   +1 more source

Paralleling insulated-gate bipolar transistors in the H-bridge structure to reduce current stress. [PDF]

SN Appl Sci, 2021
Memarian Sorkhabi M, Wendt K, Rogers D, Denison T.   +3 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Does childhood maltreatment or current stress contribute to increased risk for major depression during the menopause transition? [PDF]

Psychol Med, 2022
Bromberger JT, Chang Y, Colvin AB, Kravitz HM, Matthews KA.   +4 more
europepmc   +1 more source

DNA repair after oxidative stress: Current challenges

Current Opinion in Toxicology, 2018
Reactive oxygen and nitrogen species damage cellular macromolecules including DNA. Cells have a robust base excision repair pathway to deal with this damage in both nuclear and mitochondrial genomes. However, mitochondria lack nucleotide excision repair.
Bennett, Van Houten, Gloria A, Santa-Gonzalez, Mauricio, Camargo   +2 more
openaire   +3 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Revisiting current treatment options for stress urinary incontinence and pelvic organ prolapse: a contemporary literature review

Research and Reports in Urology, 2019
You (Maria) Wu,1 Blayne Welk21Department of Obstetrics and Gynecology, London Health Sciences Centre, London, Ontario, Canada; 2Department of Surgery and Epidemiology & Biostatistics, Western University, London, Ontario, CanadaAbstract: Stress ...
Wu Y, Welk B
doaj