Results 101 to 110 of about 64,705 (311)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Simulation of dielectric frequency response of transformer insulation system
, 2013 Frequency domain spectroscopy has been widely used to monitor the condition of insulation system in power transformers. For a core type of transformer, a simplified XY model of a duct has been developed which allows one to examine the contribution from ...
Yu, Guo, Chen, George
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Investigations into the transformer inrush current problem
, 2018 A transformer being energised may draw a large transient current from the grid supply, resulting in a temporary voltage dip at the point of connection (POC) where customers are connected. The voltage dip is dependent upon the magnitude of the transformer
Ekwue, A.O., Rawn, B
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
A New Method to Identify Fault Current and Inrush Current on Transformer by Jiles-Atherton Model
, 2012 [[abstract]]This paper proposes a new method of simulating transformer internal parameters based on voltage and current to detect transformer fault and Deformation.
Huang, Sy-Ruen; Liao, Chin-Wen; Chen, Hong-Tai; Wu, Chueh-Cheng
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
, 2013 The advent of high-temperature superconducting (HTS) materials has renewed interest in the possibilities for superconducting power apparatus offering real economic benefit, within power ratings typical of present system practice.
Sykulski, Jan K.
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