Results 51 to 60 of about 1,459,364 (299)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The nonmodal kinetic theory for the electrostatic instabilities of a plasma with a sheared Hall current

, 2019
The kinetic theory for the instabilities driven by the Hall current with a sheared current velocity, which has the method of the shearing modes or the so-called non-modal approach as its foundation, is developed. The developed theory predicts that in the
Lee, Hae June, Mikhailenko, V. S., Mikhailenko, V. V.   +2 more
core   +1 more source

Near-Bottom Velocities in Waves with a Current

Coastal Engineering 1978, 1978
Bakker (1974) developed a mathematical model concerning the sand concentration and velocity distribution in an oscillatory turbulent flow, with or without resultant current. The flow is assumed to be uniform in horizontal direction. The present paper reports on an experimental verification of this theory.
W.T. Bakker, Th. Van Doorn
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Computer Simulation of Current Forces on Motion of Floating Production Storage and Offloading in Irregular Waves [PDF]

, 2010
This paper presents the effect of current forces on the motion of forces on Floating Production Storage and Offloading (FPSO) in irregular waves. The objective of this research is to compute the motion of FPSO in irregular waves by time domain simulation
Abdul Malik, Adi Maimun, Islam, M. R., M. Kamal, M. Y., Yaakob, Omar   +3 more
core  

Nonlinear Development of Streaming Instabilities In Strongly Magnetized Plasmas

, 2009
The nonlinear development of streaming instabilities in the current layers formed during magnetic reconnection with a guide field is explored. Theory and 3-D particle-in-cell simulations reveal two distinct phases. First, the parallel Buneman instability
A. A. Galeev, A. A. Galeev, H. Che, J. F. Drake, M. Swisdak, P. H. Yoon   +5 more
core   +1 more source

Flow Velocity Profile of Micro Counter-Current Flows

Analytical Sciences, 2007
Flow velocity profiles of micro counter-current flow of aqueous and butylacetate phases in a microchannel having a width of 100 microm were measured by micro particle image velocimetry. In order to analyze the hydrodynamic characteristics of the counter-current flow, we derived a simple analytical model for the velocity profile.
Arata, Aota, Akihide, Hibara, Kyosuke, Shinohara, Yasuhiko, Sugii, Koji, Okamoto, Takehiko, Kitamori   +5 more
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Nonlinear Static Analysis of Riserless Sampling Drill String in Ultra-deepwater of South China Sea

Shiyou jixie, 2017
With the load effects of current, wave, soil, drifting of drill ship during the sampling drilling process, the rope type drill string has very complex static characteristics featuring geometric nonlinearity and contact nonlinearity.
Gao Guanghai, Qiu Xingqi, Dong Hui, Xu Junliang, Han Laiju   +4 more
doaj