Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban+12 more
wiley +1 more source
Road Maps: a guide to learning system dynamics [PDF]
MIT System Dynamics Education Project developed Road Maps, a series of self-guides, modeling and selected literature to help students and teachers learn the principles of system dynamics.
core +1 more source
Inhibiting factors affecting teachers’ implementation of the KBSM (revised) English language curriculum [PDF]
This paper aims to discuss teachers’ degree of implementation of the KBSM (Revised) English Language Curriculum, introduced in 2003. It also sets to highlight the inhibiting factors that had impeded teachers’ implementation of the Skills Specifications
Abdul Karim, Hamida Bee
core +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik+4 more
wiley +1 more source
View of curriculum experts and postgraduate students regarding the quality of students' participation in curriculum development [PDF]
The aim of this study was to investigate the postgraduate students' views regarding their current and desired participation in curriculum development and compare their views with the curriculum experts' opinions.
F. Sharifian+3 more
doaj
A model of active student participation in curriculum design: exploring desirability and possibility [PDF]
This paper explores the desirability and possibility of active student participation (ASP) in curriculum design. Rationales for pursuing ASP in curriculum design are outlined.
Bovill, C., Bulley, C.J.
core
Genetic diversity and population structure of the Taigan dog breed
The Taigan is a rare sighthound from the mountains of Kyrgyzstan. We used DNA markers to study its genetic diversity and compare it with other sighthound breeds. Our findings show that the Taigan shares close genetic ties with the Kazakh Tazy, suggesting a common ancestry shaped by nomadic traditions and regional adaptation.
Kira Bespalova+10 more
wiley +1 more source
Life, death, and ethics: medical and dental students’ attitudes on assisted dying in Austria
Background The Sterbeverfügungsgesetz (StVfG) Austria’s law on assisted dying, came into force on January 1, 2022. Since then, only limited research has examined the attitudes of medical and dental students in Austria toward assisted dying.
Carmen Trost+4 more
doaj +1 more source
Technology and science education [PDF]
The incorporation of technology into the school curriculum is part of a worldwide trend in education. The way in which technology is incorporated depends on which country the reform is initiated in.
Compton, Vicki, Jones, Alister
core +1 more source
Characterization of ribosome heterogeneity during endothelial to hematopoietic transition
The panorama of ribosome heterogeneity during embryonic hematopoiesis has not yet been portrayed. In this study, utilizing dual‐omics data, the heterogenous dynamic of ribosome during endothelial‐to‐hematopoietic transition has been systemically described. Moreover, stage‐specific upregulation and peripheral localization of RPL27 and RACK1 in hemogenic
Xitong Tian+4 more
wiley +1 more source