Results 51 to 60 of about 996,889 (306)
Inovasi Kurikulum, 2023 The demographic bonus has become unavoidable for Indonesia in 2030–2045. Will this condition be advantageous or disadvantageous depending on how HR is currently managed?
Risti Dwi Lestari
doaj +1 more source
Evaluation of the implementation process of a new mathematics curriculum for Grades 1-‐9: A discussion of the main results [PDF]
, 2012 Recently, a new Mathematics curriculum for basic education (Grades 1-9) has been introduced in the Portuguese educational system. This curriculum was designed to bring together some disperse curricular documents and to substitute the former one that was ...
Borralho, António +2 more
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The role of whole-school contexts in shaping the experiences and outcomes associated with professional development [PDF]
, 2007 Review of the article 'The role of whole-school contexts in shaping the experiences and outcomes associated with professional development'. The study examined the in-service programme in relation to different school contexts (size, type, disadvantaged ...
Harris, Linda
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
"We think that’s the future": curriculum reform initiatives in higher education [PDF]
, 2013 This research report, considering curriculum reform initiatives in higher education, explores the nature of whole institutional curriculum reform undertaken by universities in the UK, and beyond, in response to the globalised world and global economy of ...
Pegg, Ann
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Principles in Patterns (PiP) : Project Evaluation Synthesis [PDF]
, 2012 Evaluation activity found the technology-supported approach to curriculum design and approval developed by PiP to demonstrate high levels of user acceptance, promote improvements to the quality of curriculum designs, render more transparent and efficient
Macgregor, George
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Redesigning Nursing Education: Lessons Learned from the Oregon Experience [PDF]
, 2012 Offers evaluation findings, lessons learned, and guidance from a coalition of community colleges and university nursing programs that offer a standard competency-based curriculum to enable students to make a seamless transition and raise skill ...
Halley Potter, Richard D. Kahlenberg
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