Results 91 to 100 of about 261,861 (299)

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

open access: yesMolecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo   +8 more
wiley   +1 more source

CURVATURE OF THE RADIUS. [PDF]

open access: yesThe Lancet
n ...
Gibson, M. H., Gibson, M. H.
openaire   +2 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

Seed Morphology in Vitis Cultivars Related to Hebén

open access: yesAgriEngineering
Resolving the genetic relationships between cultivars is one of the objectives of research in viticulture. To this end, both DNA markers and morphological analysis help to identify synonyms and homonyms and to determine the degree of relatedness between ...
Emilio Cervantes   +6 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Infinitesimal Structure of Singularities

open access: yesUniverse, 2017
Some important problems of general relativity, such as the quantisation of gravity or classical singularity problems, crucially depend on geometry on very small scales.
Michael Heller, Jerzy Król
doaj   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

Plastic rotation and tension stiffening effect analysis in beams using photogrammetry

open access: yesRevista IBRACON de Estruturas e Materiais
Innovative procedures for monitoring experimental tests using photogrammetry and image processing have been recently proposed. This manuscript aims at providing a practical demonstration of the advantages of using these new techniques in experimental ...
R. N. F. do Carmo   +2 more
doaj   +1 more source

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