Results 121 to 130 of about 1,051,604 (281)

Investigating curvature sensing by the Nt17 domain of Huntingtin protein

ACS Chemical Neuroscience
Abstract Nt17, the N-terminal domain of the huntingtin protein (htt), has garnered significant attention for its role in htt’s membrane binding and aggregation processes. Previous studies have identified a nuclear export sequence within the Nt17 domain and demonstrated its localization at various ...
Neha Nanajkar, Abhilash Sahoo, Shelli L. Frey, Silvina Matysiak   +3 more
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

A NanoCurvS platform for quantitative and multiplex analysis of curvature-sensing proteins. [PDF]

Biomater Sci, 2023
Lu CH, Tsai CT, Jones Iv T, Chim V, Klausen LH, Zhang W, Li X, Jahed Z, Cui B.   +8 more
europepmc   +1 more source

Structural symmetry and membrane curvature sensing

, 2018
Symmetry is closely intertwined with the function, genetics, and chemical properties of multiprotein complexes. Here, we explore the relation between structural symmetry and the ability of membrane proteins to sense and induce membrane curvature, which is a key factor for modulating the shape and organization of cell membranes.
Elías-Wolff, Federico, Lyubartsev, Alexander, Brandt, Erik G., Lindén, Martin   +3 more
openaire   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Nonuniversal impact of cholesterol on membranes mobility, curvature sensing and elasticity. [PDF]

Nat Commun, 2023
Pöhnl M, Trollmann MFW, Böckmann RA.
europepmc   +1 more source

Curvature-Driven Migration of Colloids on Tense Lipid Bilayers

, 2016
Inspired by proteins that generate membrane curvature, sense the underlying membrane geometry, and migrate driven by curvature gradients, we explore the question: Can colloids, adhered to lipid bilayers, also sense and respond to membrane geometry?
Ningwei Li (3609548), Ravi Radhakrishnan (242177), Kathleen J. Stebe (187837), Tobias Baumgart (183997), Nima Sharifi-Mood (2810539), Daeyeon Lee (1341036), Fuquan Tu (1777906)   +6 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Physical forces guide curvature sensing and cell migration mode bifurcating. [PDF]

PNAS Nexus, 2023
Feng L, Zhao T, Xu H, Shi X, Li C, Hsia KJ, Zhang S.   +6 more
europepmc   +1 more source

Error Analysis of Spatial Shape Reconstruction of FBG-based Thin Plate

Guangtongxin yanjiu
【Objective】In order to realize the rapid and accurate detection and reconstruction of the spatial shape of the plate structure, a 4-point Fiber Bragg Grating (FBG) string is surface-mounted on a high-manganese steel thin plate to form a shape-sensing ...
CHA Yingpeng, CAI Jianjun, PENG Xingling
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