Results 91 to 100 of about 1,221,918 (286)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A capacitive humidity sensor using cross-linked cellulose acetate butyrate [PDF]
, 2005 This paper reports on the fabrication of a new capacitive humidity sensor having good characteristics and being robust enough to be considered as a component in industrial processes.This sensor is manufactured using a mixture of three cellulose acetate ...
Bernes, Alain +3 more
core +1 more source
Sensors, 2017 Flexible pressure sensors are increasingly being used in medical and non-medical applications, and particularly in innovative health monitoring. Their efficacy in medical applications such as compression therapy depends on the accuracy and repeatability ...
Iryna Khodasevych +2 more
doaj +1 more source
A Curvature Sensor Utilizing the Matteucci Effect in Amorphous Wire. [PDF]
Sensors (Basel), 2023 Alimohammadi S, Williams PI, Meydan T.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Secure Clustering Protocols in Wireless Sensor Networks [PDF]
, 2016 Wireless sensor networks (WSNs) are poised of huge number of low-cost and tiny devices i.e. senor nodes which communicate over wireless media. Various WSN based projects produced fruitful and interesting results that greatly improves our life.
Sharma, S C, SINGH, SANTAR PAL
core
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
In-Line Hybrid Fiber Sensor for Curvature and Temperature Measurement
IEEE Photonics Journal, 2019 We proposed and demonstrated a compact inline optical fiber sensor for curvature and temperature measurement with low cross sensitivity. The device consists of a 5 mm long hollow-core fiber (HCF) spliced between two single-mode fibers. Two up-tapers were
Haihao Cheng +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source