Results 51 to 60 of about 48,274 (223)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Dynamics Performance Analysis of Turntable Bogie Vehicles
Chengshi guidao jiaotong yanjiuObjective Compared to conventional bogies, the new type of turntable bogie exhibits smaller slewing resistance coefficients and better curve negotiation performance. Therefore, it is necessary to analyze the vehicle dynamics performance.
HU Dingxiang +4 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
机车电传动, 2012 Dynamic models of 200 km/h high-speed power cars with semi-body and flexible suspensions were established respectively, the dynamic performance of which was compared and analyzed.
王勇, 陈康
doaj
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Research on dynamic performance of tilting train with active air spring control
机车电传动, 2022 In order to study the dynamic performance of the tilting train based on the active air spring control technology, a nonlinear vertical model of the air spring and the system dynamics model of the tilting train were established, incorporating the ...
LI Zhenqian +5 more
doaj
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Performance Analysis of Piezoelectric Actuators in Railway Wheel Squealing Noise Mitigation
Shock and Vibration, 2019 Application of a shunted piezoelectric system in reduction of the squeal noise level in railway wheels is studied. A wheel squeal model including the railway track, wheel, and nonlinear interaction contact forces is taken into account in the time domain.
Seyed Rahim Marjani, Davood Younesian
doaj +1 more source