Results 61 to 70 of about 48,274 (223)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Dynamic Performance Analysis of Radial Bogie Locomotive
机车电传动, 2013 By combination of theoretical analysis and dynamic modeling and simulation, locomotive radial bogie performance of tractionand steering and hunting stability were analyzed and compared to traditional locomotive bogie.
LI Xiao-long +4 more
doaj
Research of Active Radial Device for Metro Train
Chengshi guidao jiaotong yanjiuObjective Metro trains experience wheel wear and noise issues when negotiating small radius curve section. Active radial technology for bogie wheelsets is considered an effective solution theoretically.
Huibin LIU, Wenbo NI, Shaoming MA
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Influence of Electromagnetic Force on Curve PassingDynamic Performance of LIM Metro Vehicle
机车电传动, 2016 Three-dimensional electromagnetic forces (longitudinal, vertical and lateral electromagnetic force) produced between theprimary and secondary of linear induction motor (LIM), may influence the dynamic performance of LIM vehicle.
LIU Gaokun
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Research on adaptability in horizontal curve negotiation of HTS maglev train
机车电传动To enhance the curve negotiation performance of high-temperature superconducting (HTS) maglev trains equipped with a rigid levitation frame, this paper proposes a semi-decoupled levitation frame structure with specific degrees of freedom in both pitching
LI Qiang +4 more
doaj
Design and Verification of New Head Type of Super High-speed EMUs
机车电传动, 2016 To decrease the aerodynamic drag of super high-speed EMUs, integrating high-speed EMUs head type design elements at home and abroad together, a new head type for super high-speed EMUs with speed of 500 km/h was designed.
LI Ming, LI Minggao, LIU Nan, HAN Lu
doaj
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source