Results 121 to 130 of about 320,713 (303)

Deterministic Modeling for Radiation Attenuation-integrated Radon Transform in Emission Computed Tomography: Algorithm, Curve Fitting Analysis, and Introduction of Attenuation Hadamard Matrix. [PDF]

J Med Phys, 2023
Qutbi M.
europepmc   +1 more source

Fitting the fracture curve of concrete as a density function pertaining to the generalized extreme value family

, 2017
Alfonso Fernández‐Canteli, Laura Castañon-Jano, Héctor Cifuentes, Miguel Muñiz‐Calvente, Enrique Castillo   +4 more
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Curve fitting and jump detection on nonparametric regression with missing data. [PDF]

J Appl Stat, 2023
Li Q, Li J, Cheng Y, Zhang R.
europepmc   +1 more source

Performance of Differential Evolution Method in Least Squares Fitting of Some Typical Nonlinear Curves

, 2007
Sudhanshu Mishra
openalex   +2 more sources

Voxel‐based multimodel fitting method for modeling time activity curves in SPECT images [PDF]

, 2017
David Sarrut, Adrien Halty, Jean‐Noël Badel, Ludovic Ferrer, Manuel Bardiès   +4 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Multi-curve fitting and tubulin-lattice signal removal for structure determination of large microtubule-based motors. [PDF]

J Struct Biol, 2022
Chai P, Rao Q, Zhang K.
europepmc   +1 more source

B-Spline-Based Curve Fitting to Cam Pitch Curve Using Reinforcement Learning [PDF]

, 2023
Zhiwei Lin, Tianding Chen, Yingtao Jiang, Hui Wang, Shuqin Lin, Ming Zhu   +5 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source