Results 91 to 100 of about 52,723 (304)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Recent developments in dynamic fracture: Some perspectives

, 2015
We briefly review a number of important recent experimental and theoretical developments in the field of dynamic fracture. Topics include experimental validation of the equations of motion for straight tensile cracks (in both infinite media and strip ...
Bouchbinder, Eran, Fineberg, Jay
core   +1 more source

Crack Detection and Feature Extraction of Heritage Buildings via Point Clouds: A Case Study of Zhonghua Gate Castle in Nanjing

Buildings
Zhonghua Gate Castle is on the tentative list for Chinese World Cultural Heritage. Due to long-term sunshine, rain erosion, and man-made damage, its surface appears to have different degrees of cracks and other diseases.
Helong Wang, Yufeng Shi, Qi Yuan, Mingyue Li   +3 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Nonlinear Vibration of Cracked Porous FG-GPL RC Cylindrical Panels Using a Phase-Field Crack Model

Applied Sciences
This study is concerned with the nonlinear free vibration of a cracked functionally graded porous cylindrical panel reinforced with graphene platelets by introducing a phase-field crack model.
Jin-Rae Cho
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Curvature Correction for Crack Depth Measurement Using Ultrasonic Pulse Velocity

Acoustics
This study investigates the application of Ultrasonic Pulse Velocity (UPV) for crack depth estimation in cylindrical structures, focusing on two approaches: reference measurement and dual measurement.
Dong Liu, Mengli Wu, Dimitri Donskoy
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Numerical and Experimental Studies on Crack Resistance of Ultra-High-Performance Concrete Decorative Panels for Bridges

Applied Sciences
This study develops a new type of decorative bridge panel by ultra-high-performance concrete (UHPC) based on the project of the Guangyangwan Bridge. First, the numerical analysis was carried out using MIDAS and ABAQUS to find the critical position of the
Jiongfeng Zhao, Yang Zhang, Yanyue Qin
doaj   +1 more source