Results 71 to 80 of about 52,723 (304)
Patterning of graphene for highly sensitive strain sensing on various curved surfaces
Nano Select, 2021 In recent years, graphene based flexible strain sensors have attracted great attention. Although various designed micro/nanostructure morphologies have been introduced to optimize the performance parameters such as sensitivity and working range, there ...
Wei Xu +5 more
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Ultimate behavior of idealized composite floor elements at ambient and elevated temperature [PDF]
, 2009 This paper is concerned with the ultimate behavior of composite floor slabs under extreme loading situations resembling those occurring during severe building fires.
Cashell, KA +2 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
On the tear resistance of skin. [PDF]
, 2015 Tear resistance is of vital importance in the various functions of skin, especially protection from predatorial attack. Here, we mechanistically quantify the extreme tear resistance of skin and identify the underlying structural features, which lead to ...
Gludovatz, Bernd +6 more
core +2 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Effect of crack curvature on stress intensity factors for ASTM standard compact tension specimens [PDF]
The stress intensity factors (SIF) are calculated using the method of lines for the compact tension specimen in tensile and shear loading for curved crack fronts.
Alam, J., Mendelson, A.
core +1 more source
Fractal frontiers of bursts and cracks in a fiber bundle model of creep rupture
, 2015 We investigate the geometrical structure of breaking bursts generated during the creep rupture of heterogeneous materials. Based on a fiber bundle model with localized load sharing we show that bursts are compact geometrical objects, however, their ...
Danku, Zsuzsa +2 more
core +1 more source