Results 51 to 60 of about 4,688 (263)
A Sine Curve Crack in Natural Ice [PDF]
Nature, 1935 IN January of this year, an interesting phenomenon was observed on Lake Bohinj in the Julian Alps. This lake, in the extreme north-west of Yugoslavia, is a typical alpine lake, its basin having been hollowed out by a diluvial glacier. Its altitude is 523 m., it is about 4 km. long and 1 km. wide.
openaire +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Closing Curved Crack in the Sheet Element under Action the Local Temperature Field
Механика машин, механизмов и материалов, 2013 Local changes of temperature near to the end of a curvilinear crack are considered. The problem about balance of a curvilinear crack with in part contacting beach at action of the external stretching loadings, induced thermoelastic fields of stresses and
A.B. Mustafayev
doaj
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Curved crack paths are predicted by elastic-charges
Communications MaterialsPredicting crack trajectories in brittle solids remains an open challenge due to their non-local nature and the way they modify the surrounding medium. Here, we develop a framework for analytically predicting crack paths, analogous to predicting particle
Oran Szachter +4 more
doaj +1 more source
Journal of Magnesium and AlloysMagnesium alloys with long-period stacking ordered (LPSO) structures are known for their impressive static mechanical strength, but the consistent occurrence of slip-cracking along the LPSO lamellae, which do not effectively impede the movement of basal ...
Min Zhan +9 more
doaj +1 more source