Results 41 to 50 of about 4,688 (263)
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
Propagation Law of Cracks in Surrounding Rock of Different Shape Tunnels Under Adjacent Blasting
Meikuang Anquan, 2020 To understand the effect of the tunnel section shape on the crack propagation law of surrounding rock in adjacent tunnel under blast loading, detailed research is carried out by model test and extended finite element(XFEM).
LIU Kang, GUO Dongming, ZHANG Shuai, SHI Zhenxin, CHEN Jin
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Reviews on Advanced Materials Science, 2023 In the present study, a new type of slightly curved arc HRB400 steel bars (SCAHSs) was proposed to solve the problem of temperature-induced stress loss in mass concrete structures without cutting off steel bars.
Zhuang Mei-Ling +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
INTERACTION OF CURVED CRACK FACES IN BENDING STRIP (BEAM) UNDER INFLUENCE OF TEMPERATURE FIELD
Structural Mechanics of Engineering Constructions and Buildings, 2014 Some problems of temperature field influence on the growth inhibition of curved crack in the strip (beam) when the strip is bent in the plane by given load system (constant bending moments, uniformly distributed pressure and other) is consider.
A B Mustafayev
doaj
Materials Research Express, 2021 HfB _2 -SiC composites were fabricated by the introduction of carbon fibres to meet the mechanical requirements, and hot pressing was the sintering route.
Yaxi Chen
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source