Results 31 to 40 of about 4,688 (263)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

IMPACT OF HARDENING ON J INTEGRAL AT THE SLIGHTLY CURVED ELASTICITY-PLASTICITY CRACK TIP UNDER QUASI-STATIC LOADS

open access: yesJixie qiangdu, 2016
J integral of elastic-plastic curved crack in hardened material under quasi-static loads has been mainly studied,and curved crack tip J integral has been calculated as a practical application of a second order perturbation method and theorem of surname ...
YANG DaPeng   +3 more
doaj  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

PLASTICITY AREA AT THE THREE DIMENSIONAL CURVED ELASTICITY-PLASTICITY CRACK TIP UNDER QUASI-STATIC LOAD

open access: yesJixie qiangdu, 2018
In this article,three dimensional elastic-plastic curved crack tip plasticity area under quasi-static loads has been mainly studied,and three dimensional curved crack tip plasticity area has been calculated as a practical application of a second order ...
YANG DaPeng   +3 more
doaj  

Mechanisms of Crack Evolution in Clay Materials Under Varying Boundary Conditions

open access: yesBuildings
In recent years, droughts and extreme weather events have witnessed increasing frequency around the globe, leading to a growing number of issues related to soil cracking that severely impact the stability of engineering projects and ecological ...
Guoliang Xie   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

IMPACT OF HARDENING ON PLASTICITY AREA AT THE SLIGHTLY CURVED ELASTICITY-PLASTICITY CRACK TIP UNDER QUASI-STATIC LOADS

open access: yesJixie qiangdu, 2015
In this article,elastic-plastic curved crack tip plasticity area in hardened material under quasi-static loads has been mainly studied,and curved crack tip plasticity area has been calculated as a practical application of a second order perturbation ...
YANG DaPeng, WANG JianXun, ZHAO Yao
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

IMPACT OF HARDENING ON SLIGHTLY CURVED ELASTICITY-PLASTICITY CRACK TIP DISPLACEMENT UNDER QUASI-STATIC LOADS

open access: yesJixie qiangdu, 2015
In this article,elastic-plastic curved crack tip opening displacement in hardened material under quasi-static loads has been mainly studied,and curved crack tip opening displacement has been calculated as a practical application of a second order ...
YANG DaPeng   +4 more
doaj  

Brittle-fracture simulations of curved cleavage cracks in α-iron: A molecular dynamics study

open access: yesAIP Advances, 2020
Although body-centered-cubic (bcc) metals and alloys are ubiquitous as structural materials, they are brittle, particularly at low temperatures; however, the mechanism of their brittle fracture is not fully understood.
T. Suzudo, K. Ebihara, T. Tsuru
doaj   +1 more source

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