Results 81 to 90 of about 52,723 (304)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Closing Curved Crack in the Sheet Element under Action the Local Temperature Field

Механика машин, механизмов и материалов, 2013
Local changes of temperature near to the end of a curvilinear crack are considered. The problem about balance of a curvilinear crack with in part contacting beach at action of the external stretching loadings, induced thermoelastic fields of stresses and
A.B. Mustafayev
doaj  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Evaluation of the surface strength of glass plates shaped by hot slumping process

, 2014
The Hot Slumping Technology is under development by several research groups in the world for the realization of grazing-incidence segmented mirrors for X-ray astronomy, based on thin glass plates shaped over a mould at temperatures above the ...
Basso, S., Bavdaz, M., Borsa, F., Citterio, O., Civitani, M., D'Este, A., Dall'Igna, R., Ghigo, M., Martelli, F., Pareschi, G., Parodi, G., Proserpio, L., Salmaso, B., Silvestri, M., Sironi, G., Spiga, D., Tagliaferri, G., Wille, E.   +17 more
core   +1 more source

Curved crack paths are predicted by elastic-charges

Communications Materials
Predicting crack trajectories in brittle solids remains an open challenge due to their non-local nature and the way they modify the surrounding medium. Here, we develop a framework for analytically predicting crack paths, analogous to predicting particle
Oran Szachter, Emmanuel Siéfert, Mokhtar Adda-Bedia, Eran Sharon, Michael Moshe   +4 more
doaj   +1 more source

Very high cycle fatigue resistance improvement of Mg-Gd-Zn-Zr alloy by introducing curved long-period stacking ordered lamellae

Journal of Magnesium and Alloys
Magnesium alloys with long-period stacking ordered (LPSO) structures are known for their impressive static mechanical strength, but the consistent occurrence of slip-cracking along the LPSO lamellae, which do not effectively impede the movement of basal ...
Min Zhan, Xinglin Yang, Shoucheng Shi, Yao Chen, Lang Li, Bing Xue, Yongbo Li, Wanshuang Yi, Qingyuan Wang, Chao He   +9 more
doaj   +1 more source

In silico simulation of liver crack detection using ultrasonic shear wave imaging

BMC Medical Imaging, 2018
Background Liver trauma is an important source of morbidity and mortality worldwide. A timely detection and precise evaluation of traumatic liver injury and the bleeding site is necessary.
Erwei Nie, Jiao Yu, Debaditya Dutta, Yanying Zhu   +3 more
doaj   +1 more source

Curve‐based crack detection using crack information gain

Structural Control and Health Monitoring, 2021
Qi Chen, Yuchun Huang, Xingxing Weng, Wenjun Liu   +3 more
openaire   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Thermal and electronic transport characteristics of highly stretchable graphene kirigami

, 2017
For centuries, cutting and folding the papers with special patterns have been used to build beautiful, flexible and complex three-dimensional structures.
Charlier, Jean-Christophe, Fan, Zheyong, Harju, Ari, Lherbier, Aurélien, Mortazavi, Bohayra, Rabczuk, Timon   +5 more
core   +1 more source