Results 21 to 30 of about 4,424 (262)
Interaction of surface and internal cracks in railhead
Computer Assisted Methods in Engineering and Science, 2022 This paper presents a two-dimensional model for the analysis of interaction between surface and internal cracks in the railheads subjected to wheel loading.
Manicka Dhanasekar +2 more
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Indian Journal of Dental Research, 2021 Objective: To compare and evaluate the retreatability of calcium silicate-based root canal sealers and epoxy resin-based root canal sealers in curved canals using micro-CT scanning.
M V Mavishna, Kondas Vijay Venkatesh
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Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
About measuring the stress intensity factor of cracks in curved, brittle shells
Fracture and Structural IntegrityMost techniques of measuring the stress intensity factor (SIF) in the cracking process assume a crack in a planar medium. Currently, there is no effective approach for curved brittle shells, particularly for non-developable cases, i.e., shapes with non ...
Siwen Cao, Andr�s A. Sipos
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Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Jixie qiangdu, 2019 In this article, three dimensional elastic-plastic curved crack tip opening displacement under quasi-static loads has been mainly studied, and three dimensional curved crack tip opening displacement has been calculated as a practical application of a ...
YANG DaPeng +4 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Jixie qiangdu, 2018 In this article,three dimensional elastic-plastic curved crack tip plasticity area under quasi-static loads has been mainly studied,and three dimensional curved crack tip plasticity area has been calculated as a practical application of a second order ...
YANG DaPeng +3 more
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
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