Results 31 to 40 of about 4,424 (262)
Jixie qiangdu, 2016 J integral of elastic-plastic curved crack in hardened material under quasi-static loads has been mainly studied,and curved crack tip J integral has been calculated as a practical application of a second order perturbation method and theorem of surname ...
YANG DaPeng +3 more
doaj
Mechanisms of Crack Evolution in Clay Materials Under Varying Boundary Conditions
BuildingsIn recent years, droughts and extreme weather events have witnessed increasing frequency around the globe, leading to a growing number of issues related to soil cracking that severely impact the stability of engineering projects and ecological ...
Guoliang Xie +5 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Jixie qiangdu, 2015 In this article,elastic-plastic curved crack tip plasticity area in hardened material under quasi-static loads has been mainly studied,and curved crack tip plasticity area has been calculated as a practical application of a second order perturbation ...
YANG DaPeng, WANG JianXun, ZHAO Yao
doaj
Brittle-fracture simulations of curved cleavage cracks in α-iron: A molecular dynamics study
AIP Advances, 2020 Although body-centered-cubic (bcc) metals and alloys are ubiquitous as structural materials, they are brittle, particularly at low temperatures; however, the mechanism of their brittle fracture is not fully understood.
T. Suzudo, K. Ebihara, T. Tsuru
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Jixie qiangdu, 2015 In this article,elastic-plastic curved crack tip opening displacement in hardened material under quasi-static loads has been mainly studied,and curved crack tip opening displacement has been calculated as a practical application of a second order ...
YANG DaPeng +4 more
doaj
Propagation Law of Cracks in Surrounding Rock of Different Shape Tunnels Under Adjacent Blasting
Meikuang Anquan, 2020 To understand the effect of the tunnel section shape on the crack propagation law of surrounding rock in adjacent tunnel under blast loading, detailed research is carried out by model test and extended finite element(XFEM).
LIU Kang, GUO Dongming, ZHANG Shuai, SHI Zhenxin, CHEN Jin
doaj +1 more source
Reviews on Advanced Materials Science, 2023 In the present study, a new type of slightly curved arc HRB400 steel bars (SCAHSs) was proposed to solve the problem of temperature-induced stress loss in mass concrete structures without cutting off steel bars.
Zhuang Mei-Ling +6 more
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Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source