Results 91 to 100 of about 12,049 (277)
Nuclear destabilisation – a possible genesis of cancer?
Biological Reviews, EarlyView.ABSTRACT This review examines the increasingly prominent role of mechanics within cancer formation and progression. The extremely varied and contradictory genetic landscape of cancer is in stark contrast to the seemingly universal mechanical characteristics of cancer cells and their tumour microenvironment, and mechanics may be a principal unifying ...
Daniel D. Scott +4 more
wiley +1 more source
Overnight Dexamethasone Suppression Test in the Diagnosis of Cushing's Disease
Acta Medica Iranica, 2010 Realizing the cause of Cushing's Syndrome (CS) is one of the most challenging processes in clinical endocrinology. The long high dose dexamethasone suppression test (standard test) is costly and need an extended inpatient stay.
Fatemeh Esfahanian, Rozana Kazemi
doaj
Clinical Endocrinology, EarlyView.ABSTRACT Background The diagnosis and management of childhood adrenal disorders is challenging. Clinical markers of hormone excess or deficiency may take months to manifest, and traditional biomarkers correlate only partially with clinical outcomes.
Julie Park +9 more
wiley +1 more source
Erythrocyte Na Flux in Cushing's Disease [PDF]
, 1970 Grant Gall, J C Melby, Robert Klein
openalex +1 more source
Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women
Clinical Endocrinology, EarlyView.ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan +14 more
wiley +1 more source
Genome-wide Methyl-Seq analysis of blood-brain targets of glucocorticoid exposure
Epigenetics, 2017 Chronic exposure to glucocorticoids (GCs) can lead to psychiatric complications through epigenetic mechanisms such as DNA methylation (DNAm). We sought to determine whether epigenetic changes in a peripheral tissue can serve as a surrogate for those in a
Fayaz Seifuddin +10 more
doaj +1 more source
Clinical Endocrinology, EarlyView.ABSTRACT Background Primary aldosteronism (PA) is a prevalent yet frequently underdiagnosed cause of secondary hypertension, affecting up to 10% of hypertensive individuals and contributing to increased cardiovascular risk. Accurate diagnosis is vital, as unilateral PA cases typically require surgical intervention, while bilateral disease is managed ...
Zin Htut +14 more
wiley +1 more source
Contribution of PROP1 in the pathogenesis of Cushing’s disease: A preliminary study
Interdisciplinary Neurosurgery, 2023 Prophet of Pit1 (PROP1) is the pituitary specific transcription factor which was cloned as an upstream regulator of PIT1. Cushing’s disease is caused by corticotroph adenomas which does not belong to the PIT1 lineage.
Noriyoshi Takebe +6 more
doaj
Adrenocorticotropin-Secreting Pituitary Adenomas Originate from the Anterior or the Intermediate Lobe in Cushing's Disease: Differences in the Regulation of Hormone Secretion [PDF]
, 1982 Steven W. J. Lamberts +2 more
openalex +1 more source
Differences in Clinical Presentation Between Pheochromocytomas and Paragangliomas
Clinical Endocrinology, EarlyView.ABSTRACT Objectives Pheochromocytomas and sympathetic paragangliomas (PPGLs) are similar in most aspects. However, they differ in genetic etiology, hormonal secretion, and associated neoplasms. This study aimed to investigate differences in clinical presentation between PPGLs. Design This study employs a retrospective cohort design. Patients The cohort
Vincent E. D. Pihlblad +2 more
wiley +1 more source