Results 71 to 80 of about 2,238,578 (328)

Characterizing local and systemic exposure to clobetasol propionate in healthy subjects and patients with atopic dermatitis

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims There is a potential risk of systemic side‐effects with the use of potent corticosteroids, such as clobetasol propionate (CP). This concern is of particular interest in paediatric patients. The aim of this study was to develop and verify a physiologically based pharmacokinetic (PBPK) model to describe the local and systemic exposure to CP
Janna K. Duong   +6 more
wiley   +1 more source

Clinical and Hormonal Response to Mifepristone Therapy in 2 Patients with ACTH-Independent Cushing Syndrome

open access: yesAACE Clinical Case Reports, 2015
: Objective: Cushing syndrome is an endocrine disorder resulting from prolonged exposure to excess cortisol that can lead to significant morbidity and mortality. Surgery is the first-line treatment for Cushing syndrome.
Andreas G. Moraitis, MD   +1 more
doaj  

Emergence of De Novo Conditions Following Remission of Cushing Syndrome: A Case Report and Scoping Review

open access: yesEndocrinology, Diabetes & Metabolism
Objective Onset and exacerbation of autoimmune, inflammatory or steroid‐responsive conditions have been reported following the remission of Cushing syndrome, leading to challenges in distinguishing a new condition versus expected symptomatology following
Noémie Desgagnés   +4 more
doaj   +1 more source

Harvey Cushing and Philip Hench: pituitary basophilism meets cortisone excess [PDF]

open access: yes, 2007
Universidade Federal de São Paulo (UNIFESP) Departamento de Medicina Disciplina de EndocrinologiaUniversidade Federal de Pernambuco Hospital das Clínicas Divisão de EndocrinologiaUniversity of Sheffield School of Medicine and Biomedical Science ...
Kater, Claudio Elias   +2 more
core   +1 more source

Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activity

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Prednisone is a widely used glucocorticoid in the treatment of lupus, although its dosing is often determined empirically. Prednisolone, the active metabolite of prednisone, is found in its free form in the serum. The goal of this study was to develop a population pharmacokinetic model in patients with systemic lupus erythematosus (SLE ...
Naïm Bouazza   +26 more
wiley   +1 more source

Rett Syndrome [PDF]

open access: yes, 2009
Rett syndrome is a thief! It robs little girls of their projected life. It lulls their families into a false sense of security while their little girls develop normally for 6 to 18 months.
Cox, Deborah Ann
core  

Effectiveness of medical treatment for Cushing’s syndrome: a systematic review and meta-analysis

open access: yesPituitary, 2018
PurposeTo systematically review the effectiveness of medical treatment for Cushing’s syndrome in clinical practice, regarding cortisol secretion, clinical symptom improvement, and quality of life. To assess the occurrence of side effects of these medical
L. H. Broersen   +4 more
semanticscholar   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

open access: yesBMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu   +7 more
wiley   +1 more source

A Case of Paraneoplastic Cushing Syndrome Presenting as Hyperglycemic Hyperosmolar Nonketotic Syndrome

open access: yesCase Reports in Oncology, 2017
Carcinoid tumors are neuroendocrine tumors that mainly arise in the gastrointestinal tract, lungs, and bronchi. Bronchopulmonary carcinoids have been associated with Cushing syndrome, which results from ectopic adrenocorticotrophic hormone (ACTH ...
Christina E. Brzezniak   +9 more
doaj   +1 more source

Sudden bilateral loss of vision in a 19-year-old man [PDF]

open access: yes, 2015
Introduction: Posterior Reversible Leukoencephalopathy Syndrome (PRES) is caused by ischaemia commonly affecting the posterior cerebral vasculature. It presents with sudden decreased vision, headaches, nausea, vomiting, seizures, and altered mental ...
Cauchi, David   +4 more
core  

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