Results 141 to 150 of about 650,097 (307)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Multi-Component Model Sets and Invariant Densities

, 1998
Model sets (also called cut and project sets) are generalizations of lattices, and multi-component model sets are generalizations of lattices with colourings. In this paper, we study self-similarities of multi-component model sets.
Baake, Michael, Moody, Robert V.
core   +1 more source

Development of head sample of the slug squeezing system on blooming setup of MNLZ of Belarussian metallurgical works

Литьë и металлургия, 2003
On the basis of mathematical modeling there are analyzed the different variants of placement of equipment and technology of blooms soft squeezing at casting of them at MNLZ-3 RUP ''Belarussian metallurgical works''.
V. A. Matochkin, A. V. Steblov, Ju. M. Aizin, A. V. Kuklev, A. M. Toptygin, V. V. Tinjakov   +5 more
doaj  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

International architectural workshop Patching the City 2011 [PDF]

AR: Arhitektura, Raziskave, 2012
The city of Rijeka is cut off from the sea by a strip of abandoned industrial zones. With the revitalisation of the degraded industrial areas, the city has an opportunity to progress and regain contact with the sea.
Vasa J. Perović, Anja Vidic
doaj  

Homogenization of quasiperiodic structures and two-scale cut-and-projection convergence

, 2019
Quasiperiodic arrangements of the constitutive materials in composites result in effective properties with very unusual electromagnetic and elastic properties. The paper discusses the cut-and-projection method that is used to characterize effective properties of quasiperiodic materials.
Wellander, Niklas, Guenneau, Sébastien, Cherkaev, Elena   +2 more
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Periods of cut-and-project tiling spaces obtained from root lattices

Hiroshima Mathematical Journal, 2001
In the general construction of model sets, it is interesting to know all periods of the set (or any of its associated tilings). Here, the author gives an answer for the situation where the model set is obtained by the cut and project method from a root lattice.
openaire   +3 more sources

Linear repetitivity and subadditive ergodic theorems for cut and project sets

, 2015
26 ...
Haynes, Alan, Koivusalo, Henna, Walton, James   +2 more
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source