Results 141 to 150 of about 7,299,987 (302)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Defining an optimal cut-off point for reticulocyte hemoglobin as a marker for iron deficiency anemia: An ROC analysis. [PDF]

PLoS One, 2023
Alzu'bi M, Bawa'neh H, Alshorman A, Alrawabdeh J, Odeh N, Hamadneh Y, AlAdwan M, Odeh M, Awidi A.   +8 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Selection of Raw Material Suppliers For Yarn Based on Sustainable Supply Chain Management Criteria Using Fuzzy Analytical Hierarchy Process (FAHP) and TOPSIS Methods at PT XYZ

Indonesian Journal of Social and Environmental Issues
The industrial revolution and mass production directly increased human productivity and significantly impacted the environment. Amid these environmental problems, companies created environmentally friendly production strategies and prioritized economic ...
Alma Dwi Yulia Sari, Farida Pulansari, Isna Nugraha   +2 more
doaj   +1 more source

The Optimal Cut-Off Point of the ADNEX Model for the Prediction of the Ovarian Cancer Risk [PDF]

Asian Pac J Cancer Prev, 2022
Lam Huong L, Thi Phuong Dung N, Hoang Lam V, Tran Thao Nguyen N, Minh Tam L, Vu Quoc Huy N.   +5 more
europepmc   +1 more source

How to choose cut-off points: statistical and clinical perspectives

Korean Journal of Anesthesiology
Continuous variables are often dichotomized or categorized in clinical research to improve interpretability or to align with clinical thresholds. However, arbitrary or poorly justified cut-off points can cause substantial information loss, reduced statistical power, and potentially misleading conclusions.
Boohwi, Hong, Chahyun, Oh, Sang Gyu, Kwak   +2 more
openaire   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Using Fasting Glucose and Glycated Hemoglobin in The Determination Prediabetes: A Case Report

Caucasian Medical Journal
Prediabetes (PD) is a serious health condition where glycemic levels are high, but not enough to be diagnosed as diabetes. There are still ambiguities in the diagnosis of PD.
Sevil Ismayilova
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source