Results 111 to 120 of about 968,538 (307)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Results of a Research Project about the influence of pruning intensity on cost of thinning by hand with the Variety ’Elstar’ in 2004 and 2005 [PDF]
, 2006 This trial took place in an organic fruit growing farm located near Lake Constance with the variety ‘Elstar’ planted in 1995. In 2004 and 2005 one variant (control) was pruned normally during the winter, the other variant was pruned more intensively to
Eis, Birgit
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Driven to Spend: Pumping Dollars Out of Our Households and Communities [PDF]
, 2005 This report examines the impacts of transportation spending on households in the 28 metro areas for which the federal government collects expenditure data and of rising gas prices on both households and regional economies.
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FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
The Economic Impacts of Spending Cuts and Tax Increases [PDF]
, 2004 Part of a series that examines California's budget and its relationship to the state's economy. Addresses the call on the Legislature, by the Legislative Analyst's Office, for a discussion of tax increase as part of California's long-term budget ...
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FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
Does Expansion Cause Congestion? The Case of the Older British Universities, 1994 to 2004 [PDF]
This paper examines whether the rapid growth in the number of students in British universities in recent years has led to congestion, in the sense that certain universities’ output could have been higher if this expansion had been less rapid.
David O. Allen, Tony Flegg
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