Results 181 to 190 of about 98,994 (359)

CKLF‐like MARVEL transmembrane domain‐containing superfamily 8 (CMTM8) promotes Notch signalling to maintain CD8+ T cell‐ and NK cell‐dependent tumour immune escape

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose The CKLF‐like MARVEL transmembrane domain containing superfamily (CMTM) has an important role in tumour immunity. The role of CMTM8 in tumour immune microenvironment (TIME) remains unknown. The aim was to investigate the relationship between CMTM8 and antitumour immunity. Experimental Approach Lentiviral system was established to
Fanglin Li   +14 more
wiley   +1 more source

RASD2 Drives Renal Clear Cell Carcinoma Progression via RAF1 (Ser338) Phosphorylation

open access: yesCancer Science, EarlyView.
RASD2 drives clear cell renal cell carcinoma (ccRCC) progression by physically interacting with RAF1 to induce its Ser338 phosphorylation, which subsequently activates the P38/ERK–MAPK signaling pathway to promote malignant tumor phenotypes and poor prognosis.
Jingxuan Yu   +10 more
wiley   +1 more source

T-Cell Stimulation by Melanoma RNA-Pulsed Dendritic Cells

open access: yes, 2004
In situations where well-established approaches such as surgery, radiation therapy and chemotherapy fail to help cancer patients, immunotherapy has the potential to be an effective alternative.
Javorovic, Miran
core  

MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities

open access: yesCancer Science, EarlyView.
Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah   +3 more
wiley   +1 more source

Cutaneous Melanoma in a Rabbit With Multiple Metastatic Lesions: A Case Report. [PDF]

open access: yesCase Rep Vet Med
Rostami A   +5 more
europepmc   +1 more source

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