Results 271 to 280 of about 98,994 (359)

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Acyl-CoA synthetase long-chain family member 4-A novel prognostic marker in cutaneous melanoma. [PDF]

Front Med (Lausanne)
Paria S, Lapides R, Saravi B, Rajagopal A, Torrez AM, Kölblinger P, Wang-Evers M, Manstein D, Navarini AA, Lazar P, Kemény LV, Sarek G, Adhikari K, Németh IB, Roider E.   +14 more
europepmc   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Incidence and mortality of cutaneous melanoma stratified by sex, age, and age group - An analysis of the Brazilian population from 2013 to 2023. [PDF]

An Bras Dermatol
Cardial DT, Paschoal FM, Sousa LVA.
europepmc   +1 more source

Prognostic Value of Non-nodal Regional Metastases in Predicting Sentinel Lymph Node Status in Cutaneous Melanoma: Multicenter Analysis of the Sentinel Lymph Node Working Group Database [PDF]

Nazia Riaz, Stanley P. Leong, Mohammed Kashani-Sabet, R. L. White, John T. Vetto, Schlomo Schneebaum, Cristina O’Donoghue, J. Harrison Howard, Eli Avisar, Jukes P. Namm, Heidi Kosiorek, Barbara Pockaj, Mark B. Faries, Giorgos Karakousis, Jonathan S. Zager, Roger Olofsson Bagge   +15 more
openalex   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

Cutaneous melanoma in Kazakhstan: epidemiological trends and economic burden on the healthcare system. [PDF]

Arch Public Health
Adilova A, Ussatayeva G, Izbagambetov N, Zhakhina G, Sagyndykov M, Adilov R.   +5 more
europepmc   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Multimodality Imaging in Cardiac Metastasis of Cutaneous Melanoma: Case Report and Systematic Review. [PDF]

J Cardiovasc Dev Dis
Lara-Sampayo KL, Ibarrola-Peña JC, de la Pena-Tamez M, Salinas-Casanova JA, Garcia R, Jerjes-Sanchez C, Paredes-Vazquez JG, de la Pena-Almaguer E.   +7 more
europepmc   +1 more source

Metabolic Parameters on Baseline and Early [18F]FDG PET/CT as a Predictive Biomarker for Resistance to BRAF/MEK Inhibition in Advanced Cutaneous BRAFV600-mutated Melanoma [PDF]

Bernies van der Hiel, Berlinda J. de Wit–van der Veen, Alfons J.M. van den Eertwegh, Wouter V. Vogel, Marcel P. M. Stokkel, Marta López‐Yurda, Ronald Boellaard, Ellen Kapiteijn, Geke A.P. Hospers, Maureen J.B. Aarts, Filip De Vos, Marye J. Boers‐Sonderen, Astrid A.M. van der Veldt, Jan Willem B. de Groot, John B.A.G. Haanen   +14 more
openalex   +1 more source