Results 261 to 270 of about 134,257 (306)
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The Lancet, 2014
In the past decade, major advances have been made in the understanding of melanoma. New predisposition genes have been reported and key somatic events, such as BRAF mutation, directly translated into therapeutic management. Surgery for localised melanoma and regional lymph node metastases is the standard of care.
Alexander M M, Eggermont +2 more
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In the past decade, major advances have been made in the understanding of melanoma. New predisposition genes have been reported and key somatic events, such as BRAF mutation, directly translated into therapeutic management. Surgery for localised melanoma and regional lymph node metastases is the standard of care.
Alexander M M, Eggermont +2 more
openaire +2 more sources
The Journal of Dermatology, 1994
AbstractSeventeen consecutive patients no older than 14 years with cutaneous melanoma were observed from 1975 to 1991 at the Istituto Nazionale Tumori, Milan; this series represented 0.8% of all cutaneous melanomas observed at the Institute during this period. Ten were males and seven females. Nine lesions arose on limbs, seven on the trunk, and one on
C, Bartoli +6 more
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AbstractSeventeen consecutive patients no older than 14 years with cutaneous melanoma were observed from 1975 to 1991 at the Istituto Nazionale Tumori, Milan; this series represented 0.8% of all cutaneous melanomas observed at the Institute during this period. Ten were males and seven females. Nine lesions arose on limbs, seven on the trunk, and one on
C, Bartoli +6 more
openaire +2 more sources
Seminars in Cancer Biology, 2000
Members of some kindreds have a hereditary predisposition for development of cutaneous melanoma. Cytogenetic and linkage studies implicated chromosomes 1p and 9p as possible locations for genetic alterations predisposing for melanoma. Germline mutations in the CDKN2A gene on chromosome 9p21 have been identified in hereditary melanoma, but are present ...
Anton Platz, U Ringborg, J Hansson
exaly +3 more sources
Members of some kindreds have a hereditary predisposition for development of cutaneous melanoma. Cytogenetic and linkage studies implicated chromosomes 1p and 9p as possible locations for genetic alterations predisposing for melanoma. Germline mutations in the CDKN2A gene on chromosome 9p21 have been identified in hereditary melanoma, but are present ...
Anton Platz, U Ringborg, J Hansson
exaly +3 more sources
Cutaneous melanoma in the elderly
Melanoma Research, 2009The aim of this review was to analyze the difficulties in diagnosing and treating elderly patients with cutaneous melanoma. It focused on the main causes for late diagnosis and relatively poor prognosis in these patients. Early detection of melanoma is vital to reduce mortality in these patients and surgery is often curative.
Testori A. +8 more
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Epigenetics of Cutaneous Melanoma
Advances in Dermatology, 2008Tumorigenesis is traditionally thought to be caused by the imbalance between oncogenes and tumor-suppressor genes. Epigenetics is a recently described phenomenon that uses an alternative mechanism to explain the transcriptional inactivation of tumor-suppressor genes predominantly by hypermethylation of the promoter regions.
Willmar D, Patino, Joseph, Susa
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Screening for Cutaneous Melanoma
Surgical Oncology Clinics of North America, 2005Current data do not support widespread population-based screening for melanoma. While the incidence of melanoma is high, the overall mortality is low, and thus any potential benefit of screening the general population is hard to demonstrate. No randomized controlled trial showing reduction in mortality has ever been completed and, given the expense and
Julie R, Lange, Charles M, Balch
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Metastasectomy in cutaneous melanoma
European Journal of Surgical Oncology (EJSO), 2017Metastasectomy remains the only treatment in malignant melanoma to offer complete pathologic response within a few days of in-hospital stay. It has been historically associated with the highest survival rates in the literature reported for patients of this stage.
K, Lasithiotakis, O, Zoras
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Journal of the American Academy of Dermatology, 1991
C UTANEOUS MALIGNANT melanoma (CMM) is a cancer that arises in the melanin-producing cells called melanocytes. It is one of the most easily detected cancers, as the patient usually presents with a skin lesion that is readily visible. Melanomas that are detected early are almost always curable by surgical excision.’ With this in mind, the importance of ...
C, Grin-Jorgenson, A W, Kopf, J C, Maize
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C UTANEOUS MALIGNANT melanoma (CMM) is a cancer that arises in the melanin-producing cells called melanocytes. It is one of the most easily detected cancers, as the patient usually presents with a skin lesion that is readily visible. Melanomas that are detected early are almost always curable by surgical excision.’ With this in mind, the importance of ...
C, Grin-Jorgenson, A W, Kopf, J C, Maize
openaire +4 more sources
Cutaneous Melanomas of the Eyelid
Seminars in Ophthalmology, 2006Cutaneous eyelid melanomas are very rare lesions. The lentiginous subtypes are the most frequent melanocytic lesions of the eyelid and can be likened to conjunctival melanocytic lesions like PAM, PAM with atypia and conjunctival melanoma. Compared to melanomas elsewhere on the body, eyelid melanomas have special considerations. Eyelid skin is very thin,
Patrick R, Boulos, Peter A D, Rubin
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Epidemiology of Cutaneous Melanoma
Dermatologic Clinics, 1985Although intermittent intense solar exposure and genetic traits such as fair skin continue to be associated with the risk of developing cutaneous melanoma, these factors fail to account for much of the incidence. Suggestive evidence has increased speculation that viral agents, radiation, hormones, chemicals in the workplace, and dietary factors play ...
R A, Lew, H K, Koh, A J, Sober
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