Results 11 to 20 of about 417 (120)

HISTOLOGY, DIMENSIONS, AND FLUORESCEIN STAINING CHARACTERISTICS OF NODULAR AND CUTICULAR DRUSEN IN AGE-RELATED MACULAR DEGENERATION [PDF]

Retina, 2023
Purpose: To enable in vivo analysis of drusen composition and lifecycle, the macular nodular and cuticular drusen were assessed using histology. Methods: Median and interquartile range of base widths of single (nonconfluent) nodular drusen in three sources were determined ...
Jeffrey D Messinger, Murray C Killingsworth, K Bailey Freund   +2 more
exaly   +6 more sources

Whole Exome Sequencing in Patients with the Cuticular Drusen Subtype of Age-Related Macular Degeneration. [PDF]

PLoS ONE, 2016
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly people worldwide. Cuticular drusen (CD) is a clinical subtype of AMD, which typically displays an earlier age at onset, and has a strong genetic component ...
Maheswara R Duvvari, Johannes P H van de Ven, Maartje J Geerlings, Nicole T M Saksens, Bjorn Bakker, Arjen Henkes, Kornelia Neveling, Marisol del Rosario, Dineke Westra, Lambertus P W J van den Heuvel, Tina Schick, Sascha Fauser, Camiel J F Boon, Carel B Hoyng, Eiko K de Jong, Anneke I den Hollander   +15 more
doaj   +9 more sources

Complement Factor H Polymorphism p.Tyr402His and Cuticular Drusen [PDF]

JAMA Ophthalmology, 2007
To determine the histidine frequency in patients with the cuticular drusen phenotype of age-related macular degeneration (AMD).Fifty individuals were identified who met the criteria for the cuticular drusen phenotype using a standard threshold photograph. We genotyped DNA samples using a polymerase chain reaction-based restriction digest assay.
Michael A Grassi, James C Folk, Todd E Scheetz   +2 more
exaly   +4 more sources

Structural Biomarkers Influencing Drusenoid Pigment Epithelial Detachment Lifecycle and the Development of Late Macular Degeneration [PDF]

Ophthalmology Science
Purpose: Drusenoid pigment epithelial detachment (dPED) is a notable phenotype in age-related macular degeneration (AMD), often evolving into macular complications such as macular neovascularization (MNV) and geographic atrophy (GA).
Serena Fragiotta, MD, PhD, Giuseppe Querques, MD, PhD, Maria Sole Polito, MD, Eliana Costanzo, MD, Tommaso Rossi, MD, Monica Varano, MD, Francesca Maria Pannarale, MD, Yoichi Sakurada, MD, Mariacristina Parravano, MD   +8 more
doaj   +3 more sources

Cuticular Drusen [PDF]

Ophthalmology, 2018
Purpose: To define the range and life cycles of cuticular drusen phenotypes using multimodal imaging and to review the histologic characteristics of cuticular drusen.
Chandrakumar Balaratnasingam, Svetlana Cherepanoff, Rosa Dolz-Marco   +2 more
exaly   +4 more sources

Developing an image-based grading scale for peripheral drusen to investigate associations of peripheral drusen type with age-related macular degeneration [PDF]

Scientific Reports
Age-related macular degeneration (AMD) is a leading cause of blindness. It is associated with peripheral drusen which has not been categorized. We investigated peripheral drusen to validate an image grading system and to understand possible associations ...
Paripoorna Sharma, Fritz Gerald P. Kalaw, Andrew Lin, Evan H. Walker, Shyamanga Borooah   +4 more
doaj   +3 more sources

Adaptive Optics-Transscleral Flood Illumination Imaging of Retinal Pigment Epithelium in Dry Age-Related Macular Degeneration [PDF]

Cells
Adaptive optics-transscleral flood illumination (AO-TFI) is a novel imaging technique with potential for detecting retinal pigment epithelium (RPE) changes in dry age-related macular degeneration (AMD).
Laura Kowalczuk, Rémy Dornier, Aurélie Navarro, Fanny Jeunet, Christophe Moser, Francine Behar-Cohen, Irmela Mantel   +6 more
doaj   +3 more sources

Cuticular drusen: Age-related macular degeneration in the young - A case report

Indian Journal of Ophthalmology. Case Reports, 2021
A 30-year-old woman presented to the OPD, and during the course of her retinal examination she was seen to have multiple drusen in both the eyes.
Saarang Hansraj, Aliya Sultana, Rajalingam Vairagyam   +2 more
doaj   +2 more sources

Analysis of rare variants in the CFH gene in patients with the cuticular drusen subtype of age-related macular degeneration. [PDF]

Mol Vis, 2015
PURPOSE: Age-related macular degeneration (AMD) and cuticular drusen (CD), a clinical subtype of AMD, have been linked to genetic variants in the complement factor H (CFH) gene. In this study, we aimed to investigate the frequency of rare variants in the CFH gene in 180 cases with CD.
Duvvari MR, Saksens NT, van de Ven JP, de Jong-Hesse Y, Schick T, Nillesen WM, Fauser S, Hoefsloot LH, Hoyng CB, de Jong EK, den Hollander AI.   +10 more
europepmc   +10 more sources

Cuticular drusen presenting with central serous chorioretinopathy in both eyes: A case report. [PDF]

Medicine (Baltimore), 2022
Rationale: Drusen are precursor lesions to advanced age-related macular degeneration. Although cuticular drusen are located between the retinal pigment epithelium and Bruch’s membrane, as are conventional drusen, they possess unique characteristics that are distinct from those of conventional drusen on clinical presentations ...
Hosoda S, Sakurada Y, Shijo T, Kashiwagi K.   +3 more
europepmc   +3 more sources