Results 111 to 120 of about 763,744 (316)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Nature CommunicationsSo-called Z-scheme systems permit overall water splitting using narrow-bandgap photocatalysts. To boost the performance of such systems, it is necessary to enhance the intrinsic activities of the hydrogen evolution photocatalyst and oxygen evolution ...
Lihua Lin +13 more
doaj +1 more source
, 2003 Title from caption list supplied by the photographer, see file NLA04/564.; Inscriptions: Signed by the photographer in pencil on reverse; "14-19"--in pencil on reverse.; Part of the collection: A blood red noon, photography of the Brindabella & southern ...
Cutting, Jeff, 1945-
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Considerations for Discrete Element Modeling of Rock Cutting [PDF]
, 2013 This study attempts to build a framework within the Discrete Element Method (DEM) to produce a reliable predictive tool in rock cutting applications, such that the cutting forces and fragmentation process are reasonably estimated. The study is limited to
Mendoza Rizo, Jorge Alejandro
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Pre-evaluation on surface profile in turning process based on cutting parameters [PDF]
, 2009 Traditional online or in-process surface profile (quality) evaluation (prediction) needs to integrate cutting parameters and several in-process factors (vibration, machine dynamics, tool wear, etc) for high accuracy.
MA, Ning +3 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2015 The need for high quality machining of composite materials is rising due to the increased utilisation of these materials across several applications. This paper presents experimental findings of orthogonal cutting of unidirectional glass fibre reinforced
Kahwash, Fadi +5 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source