Results 111 to 120 of about 914,536 (301)
DEFLECTIONS AND FREQUENCY ANALYSIS IN THE MILLING OF THIN-WALLED PARTS WITH VARIABLE LOW STIFFNESS
Acta Polytechnica, 2019 The disadvantage of the geometry of thin-walled parts, in terms of processing, is the low ability to resist static and dynamic loads. It is caused by the elastic deformation of elements with a low stiffness.
Serhii Kononenko +4 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Two-person pie-cutting: The fairest cuts [PDF]
Barbanel, Brams, and Stromquist (2009) asked whether there exists a two-person moving-knife procedure that yields an envy-free, undominated, and equitable allocation of a pie.
Brams, Steven J., Barbanel, Julius B.
core
2005 IEEE Computer Society Conference on Computer Vision and Pattern Recognition (CVPR'05), 2005 In this paper, we present a principled Bayesian method for detecting and segmenting instances of a particular object category within an image, providing a coherent methodology for combining top down and bottom up cues. The work draws together two powerful formulations: pictorial structures (PS) and Markov random fields (MRFs) both of which have ...
Kumar, MP, Torr, PHS, Zisserman, A
openaire +3 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Fundamental Study into the Mechanics of Material Removal in Rock Cutting [PDF]
The objective of this work was to understand the mechanics of material removal during rock cutting. The exact nature of the failure of the rock material at the tool tip was investigated using a single cutting tooth test rig coupled with high speed ...
Aresh, Balaji
core
Design and analysis of a piezoelectric film embedded smart cutting tool [PDF]
, 2013 This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2012 Institution of Mechanical Engineers.The condition of a cutting tool is an important factor for manufacturing processes.
Cheng, K, Rakowski, R
core +1 more source
Nature CommunicationsSo-called Z-scheme systems permit overall water splitting using narrow-bandgap photocatalysts. To boost the performance of such systems, it is necessary to enhance the intrinsic activities of the hydrogen evolution photocatalyst and oxygen evolution ...
Lihua Lin +13 more
doaj +1 more source