Results 101 to 110 of about 919,769 (305)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Directional cohesive elements for blade cutting simulations of layered shells [PDF]

, 2016
The blade cutting of thin layered shell involves three small geometrical scales, the scale of layer thicknesses, the scale of blade radius of curvature, the scale of fracture and delamination process zones, which need be resolved when a numerical ...
Confalonieri, Federica, Ghisi, ALDO FRANCESCO, Mirzapour, Jamil, Perego, Umberto   +3 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Некоторые методологические принципы создания функциональных покрытий для режущего инструмента [PDF]

, 2010
В статье представлены методологические принципы создания функциональных покрытий для режущего инструмента. Разработанная высокопрочная композиционная керамика с наноструктурированным покрытием позволяет повысить стойкость режущего инструмента до 2-3 раз ...
Верещака, А. А., Верещака, А. С.   +1 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Enhancing the Digital Inheritance and Development of Chinese Intangible Cultural Heritage Paper-Cutting Through Stable Diffusion LoRA Models

Applied Sciences
With the advent of artificial intelligence digitization, intangible cultural heritage faces challenges in preservation and transmission. Utilizing modern technology to achieve digital protection and dissemination has become a crucial issue today.
Mengge Dai, Yuhao Feng, Runqi Wang, Jungho Jung   +3 more
doaj   +1 more source

Reduction of the mesh size influence on the results of a lagrangian finite element machining mode [PDF]

, 2017
Mesh dependence of the results of a finite element model are well known in many fields such as in structural design. This problem is however not much addressed in the literature for machining modelling although it is crucial for the quality of the results ...
Ducobu, François, Filippi, Enrico, Riviere-Lorphevre, Edouard   +2 more
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Continuous chip cutting in double edge turning by tool with elctromechanical link [PDF]

, 2012
Проведено експериментальні дослідження подрібнення зливної стружки при дволезовому точінні інструментами з електромеханічним зв’язком. Проаналізовано стружкоутворення при різних режимах для різних матеріалів обробки.
Lutsiv, I., Shtogryn, S., Луців, Ігор Володимирович, Штогрин, Степан   +3 more
core   +1 more source