Results 101 to 110 of about 918,916 (305)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Некоторые методологические принципы создания функциональных покрытий для режущего инструмента [PDF]

, 2010
В статье представлены методологические принципы создания функциональных покрытий для режущего инструмента. Разработанная высокопрочная композиционная керамика с наноструктурированным покрытием позволяет повысить стойкость режущего инструмента до 2-3 раз ...
Верещака, А. А., Верещака, А. С.   +1 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Enhancing the Digital Inheritance and Development of Chinese Intangible Cultural Heritage Paper-Cutting Through Stable Diffusion LoRA Models

Applied Sciences
With the advent of artificial intelligence digitization, intangible cultural heritage faces challenges in preservation and transmission. Utilizing modern technology to achieve digital protection and dissemination has become a crucial issue today.
Mengge Dai, Yuhao Feng, Runqi Wang, Jungho Jung   +3 more
doaj   +1 more source

Reduction of the mesh size influence on the results of a lagrangian finite element machining mode [PDF]

, 2017
Mesh dependence of the results of a finite element model are well known in many fields such as in structural design. This problem is however not much addressed in the literature for machining modelling although it is crucial for the quality of the results ...
Ducobu, François, Filippi, Enrico, Riviere-Lorphevre, Edouard   +2 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Technoeconomic and thermodynamic aspects of the edge cutting machining optimization

Advanced Engineering Research, 2016
The investigation objective is to develop a calculation method of selecting the optimum cutting speed corresponding to the minimum tool-wear rate. The analysis of the known optimization criteria such as tribological, thermal, energy and thermodynamic ...
Anatoliy A. Ryzhkin, Juliya A. Oleynikova, Denis V. Moiseev, Evgeniy V. Fominov   +3 more
doaj   +1 more source

Continuous chip cutting in double edge turning by tool with elctromechanical link [PDF]

, 2012
Проведено експериментальні дослідження подрібнення зливної стружки при дволезовому точінні інструментами з електромеханічним зв’язком. Проаналізовано стружкоутворення при різних режимах для різних матеріалів обробки.
Lutsiv, I., Shtogryn, S., Луців, Ігор Володимирович, Штогрин, Степан   +3 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source