Results 131 to 140 of about 918,916 (305)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Exploration of Yangzhou Paper-cutting Elements based on Laser Technology and their Application in Leather Garments

Pige Kexue Yu Gongcheng
As one of China's intangible cultural heritage, Yangzhou paper-cutting art is a typical representative of Yangzhou folk culture. We summarized and analyzed the representative works of Yangzhou paper-cutting masters, extracted the paper-cutting patterns ...
Beilu HE, Qiyue QIAN, Jinchao ZHOU
doaj   +1 more source

Finite element mechanical analysis of civil cutting tools for bone cutting

Journal of Physics: Conference Series
Abstract By conducting finite element analysis on the process of bone cutting using Ansys, it was found that the cutting edge angle and cutting speed of different material tools have a significant impact on the performance of the workpiece and tool.
Weigui Zhai, Yuanzhi Zhu, Yuejie Shi, Ying Zhao   +3 more
openaire   +1 more source

Analytical prediction of stability limit in turning operations [PDF]

, 2006
Unstable cutting due to chatter vibrations is one of the most important problems during metal cutting operations. Chatter can be a limitation for productivity and surface quality in turning operations, especially when long and slender tools and parts are
Budak, Erhan, Ozlu, Emre, Özlü, Emre
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Fatigue test bench manufacturing by reusing a parallel lathe [PDF]

, 2018
Fatigue life of machined parts strongly depends on their surface condition. The rotating bar bending fatigue testing method is widely used to obtain the fatigue behavior of metallic materials due to its simplicity.
Bermudo Gamboa, Carolina, Martín Béjar, Sergio, Sevilla-Hurtado, Lorenzo, Trujillo Vilches, Francisco Javier   +3 more
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Fly-Cutting Processing of Micro-Triangular Pyramid Arrays and Synchronous Micro-Scrap Removal

Micromachines
Many micro-scraps are generated when a micro-triangular pyramid array (MTPA) is machined by the fly-cutting method. Micro-scraps are generally not removed quickly enough; therefore, these residual micro-scraps participate in the cutting process again ...
Jiashun Gao, Zhilong Xu, Yu Lei, Su Huang   +3 more
doaj   +1 more source