Results 41 to 50 of about 89,685 (265)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Cutting Force and Cutting Quality during Tapered Milling of Glass Magnesium Board

Applied Sciences, 2019
In this paper, the effects of tool geometry and cutting parameters on cutting force and quality were investigated during the tapered milling of glass magnesium (MGO) board with diamond cutters. The results were as follows: firstly, both the cutting force
Pingxiang Cao, Zhaolong Zhu, Xiaolei Guo, Xiaodong (Alice) Wang, Chunchao Fu, Chi Zhang   +5 more
doaj   +1 more source

Research on abrasive wear dress of CBN honing tool based on single abrasive cutting

Jin'gangshi yu moliao moju gongcheng, 2022
The abrasive wear characteristics of large length to diameter ratio CBN single-pass honing tools during ultrasonic dressing process were studied by single abrasive test with 4Cr13 stainless steel as dressing material.
Changyong YANG, Nianhui ZHANG, Hao SU, Wenfeng DING   +3 more
doaj   +1 more source

Forces and Plastic Work in Cutting

CIRP Annals, 1983
Prolific considerations in C.I.R.P. give rise to a further step in the development of a plastic cutting model. Basically two different primary shear zone geometries are assumed: with one and with two shear planes respectively. For both geometries two energetically different approaches are developed.
Dautzenberg, J.H., Kals, J.A.G., van der Wolf, A.C.H.   +2 more
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Design and Study on the Cutting Structure of Rotary Cutting PDC Bit

Shiyou jixie, 2020
The rotary cutting PDC bit can well adapt to deep high-plasticity strata. In this paper, the cutting performance of rotary cutting PDC bit was investigated by means of experiment and simulation.
Cao Yang, Wang Haitao
doaj  

Research into mechanical modeling based on characteristics of the fracture mechanics of ice cutting for scientific drilling in polar regions [PDF]

The Cryosphere
Scientific drilling in polar regions plays a crucial role in obtaining ice cores and using them to understand climate change and to study the dynamics of polar ice sheets and their impact on global environmental changes (sea level, ocean current cycle ...
X. Lv, X. Lv, Z. Cui, Z. Cui, T. Wang, Y. Wen, A. Liu, R. Wang, R. Wang   +8 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Cutting Force Prediction in Drilling of Titanium Alloy

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
Cutting force in drilling of Ti-6Al-4V is studied with simulation based on a predictive model. In the force model, three-dimensional chip flow is made by piling up the orthogonal cuttings in the planes containing the cutting velocities and the chip flow ...
Shoichi TAMURA, Takashi MATSUMURA, Pedro J. ARRAZOLA   +2 more
doaj   +1 more source

Perancangan Dinamometer untuk Mengukur Gaya Potong pada Mesin Freis untuk Pemesinan Material Fiber Reinforced Polymer

Metal: Jurnal Sistem Mekanik dan Termal, 2020
Milling machine is a machine that cuts a workpiece using a plural chisel that rotates on a freis machine. During the freis process, the material is cut because of the cutting force that occurs between the tool and the workpiece.
Firman Ridwan, Refki Harvendri
doaj   +1 more source