Results 51 to 60 of about 1,596,362 (297)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Investigation of the Relationship between Vibration, Cutting Forces and Tool Wear During the Processing of Inconel 718 Super Alloy under Coolant Pressure Jet-Assisted Turning with Variance Analysis

Mehmet Akif Ersoy Üniversitesi Fen Bilimleri Enstitüsü, 2020
In this study, cutter vibrations, wear conditions and cutting forces are observed during jet-assisted turning under coolant pressure conditions. Inconel 718 material is used as a thread.
Orhan GÜNGÖR, Hüseyin Bilal MACİT
doaj   +1 more source

The analysis of cutting forces for hardened steel milling

Омский научный вестник, 2023
Micro milling is a widely used manufacturing method. The main purpose of this study is to analyze the cutting forces in corrosion-resistant, heat-resistant steel 14Kh17N2.
D. S. Makashin
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Influence of Cutting Fluid Application Frequency in Micromilling Cutting Forces

International Journal of Engineering Materials and Manufacture, 2021
Micromachining allows the production of parts and components on a micro scale with high precision and has become a key process to meet the growing demand for micro parts and micro components. To meet the quality requirements of the generated surfaces and
Deborah De Oliveira, Milla Caroline Gomes, Aline Gonçalves dos Santos, Marcio Bacci Da Silva   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A predictive model for the cutting force in wood machining developed using mechanical properties [PDF]

, 2012
In this study a number of work piece variations were evaluated whilst limiting the cutting conditions. Eight wood species controlled at four moisture levels were machined along and across the wood grain.
Andrew Naylor,, Perera, Noel, Emil Clahr, Noel Perera,, Naylor, Andrew, Hackney, Philip, Phil Hackney,, Clahr, Emil   +7 more
core   +1 more source

Numerical and analytical modeling of orthogonal cutting : The link between local variables and global contact characteristics [PDF]

, 2011
The response of the tool–chip interface is characterized in the orthogonal cutting process by numerical and analytical means and compared to experimental results. We study the link between local parameters (chip temperature, sliding friction coefficient,
Miguélez Garrido, María Henar, R. Cheriguene, MOLINARI, Alain, CHERIGUENE, Rachid, MIGUELEZ, Henar, A. Molinari, Molinari, A., H. Miguelez   +7 more
core   +1 more source

Determination of Optimum Machining Parameters in Machining Rene 41 Superalloy Depending on Cutting Speed [PDF]

E3S Web of Conferences
Rene 41 superalloy developed to withstand severe mechanical stresses and high temperature operation, and are widely used in aircraft and space vehicles, especially nickel-based ones, due to their high corrosion resistance.
Altin Abdullah, Altin Muhammed Cihat, Altin Hilal, Altin Tuğba   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source