Results 71 to 80 of about 1,596,362 (297)

THE INFLUENCE OF THE FUNCTIONAL GEOMETRY OF THE CUTTING TOOLON THE MAINCUTTINGFORCE IN THE STRING OPERATION [PDF]

Analele Universităţii "Constantin Brâncuşi" din Târgu Jiu: Seria Inginerie, 2018
he quality of the machined parts is strongly influenced by the rigidity of the technological system, but also by the size and variation of the forces that occur during the cutting process.
D. Dobrotă, M. Tomescu
doaj  

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Effect of cryogenic treatment of tungsten carbide tools on cutting force and power consumption in CNC milling process

Production and Manufacturing Research: An Open Access Journal, 2018
In this paper, the effect of Deep Cryogenic Treatment (DCT) soaking duration on tungsten carbide end mill cutters on cutting forces and power consumption during machining P20 mold steel in CNC milling machine is investigated and optimized the process ...
Vishnu Vardhan Mukkoti, G. Sankaraiah, M. Yohan   +2 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

The Effect of Technique Change on Knee Loads during Sidestep Cutting [PDF]

, 2007
PURPOSE: To identify the effect of modifying sidestep cutting technique on knee loads and predict what impact such change would have on the risk of noncontact anterior cruciate ligament injury.
Elliott, Bruce C, Dempsey, A.R., Elliott, B.C., Steele, J.R., Dempsey, Alasdair R, Munro, B.J., Russo, K.A., Munro, Bridget J, Lloyd, David G, Russo, Kylie A, Lloyd, D.G., Steele, Julie R, JULIE R. STEELE, BRIDGET J. MUNRO, BRUCE C. ELLIOTT, ALASDAIR R. DEMPSEY, DAVID G. LLOYD, KYLIE A. RUSSO   +17 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Dynamic analysis of runout correction in milling [PDF]

, 2010
Tool runout and its effects is an important area of research within modelling, simulation, and control of milling forces. Tool runout causes tool cutting edges to experience uneven forces during milling.
Guzman Villaseñor, Mario, Perez Garcia, Hilde, Diez Cifuentes, Eduardo, Vizán Idoipe, Antonio   +3 more
core   +1 more source

Machinability analysis on helical milling of carbon fiber reinforced polymer

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2015
In the helical milling process, a rotating tool traverses a helical trajectory to generate a hole. In order to investigate the cutting state in helical milling of carbon fiber reinforced polymer(CFRP), experiments were conducted with unidirectional and ...
Haiyan WANG, Xuda QIN, Hao LI
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source