Results 61 to 70 of about 1,596,362 (297)

The effect of cutting conditions, insert coating type, and cooling on cutting forces during face finish milling of high-strength spheroidal grade cast iron

Технічна інженерія
This article presents the results of an experimental study of cutting forces during face finishing of high-strength spheroidal graphite cast iron EN-GJS-600-3 using a Sandvik Coromant R200-051Q22-12H face milling cutter with round carbide inserts ...
S.I. Radkevych, V.M. Ruban
doaj   +1 more source

Artificial Neural Network System for Predicting Cutting Forces in Helical-End Milling of Laser-Deposited Metal Materials

Tehnički Glasnik, 2023
When machining difficult-to-cut metal materials often used to make sheet metal forming tools, excessive cutting force jumps often break the cutting edge. Therefore, this research developed a system of three neural network models to accurately predict the
Uroš Župerl, Miha Kovačič
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A new approach of high speed cutting modelling: SPH method [PDF]

, 2006
The purpose of this study is to introduce a new approach of high speed cutting numerical modelling. A lagrangian Smoothed Particle Hydrodynamics (SPH) based model is carried out using the Ls-Dyna software.
J. Limido, Salaün, Michel, J.L. Lacome, Lacome, Jean-Luc, M. Salaun, C. Espinosa, Espinosa, Christine, Limido, Jérôme   +7 more
core   +1 more source

Finite Element Analysis of Orthogonal Cutting Forces in Machining AISI 1020 Steel Using a Carbide Tip Tool

Журнал інженерних наук, 2018
Force modeling in metal cutting is important for various purposes, including thermal analysis, tool life estimation, chatter prediction, and tool condition monitoring.
Bashistakumar M., Pushkal B.
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Experimental study of coated carbide tools behaviour: application for Ti-5-5-5-3 turning [PDF]

, 2011
The goal of this paper is to study the relation between the input data (conditions and geometry of cut) and answers (wear of tool, forces and cutting temperatures) when machining the Ti-5-5-5-3 alloy treated. This study has shown that the cutting process
Wagner, Vincent, V. Wagner, Baili, Maher, Lallement, Daniel, M. Baili, G. Dessein, Dessein, Gilles, D. Lallement   +7 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

A review of wood machining literature with a special focus on sawing [PDF]

, 2013
In this review, fundamental wood machining research is evaluated to determine the general cutting mechanics of simple, orthogonal, and oblique cutting tools. Simple tool force trends and chip formation characteristics are indentified here, along with the
Phil Hackney, Naylor, Andrew, Hackney, P, Hackney, Philip, Andrew Naylor, Naylor, A   +5 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source