Results 91 to 100 of about 390,130 (351)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Trudy Odesskogo Politehničeskogo Universiteta, 2014 At elongated holes boring several imperfections can occur, namely, the surface waviness and shape inaccuracies in the axial section. This research purpose is to establish the regularities of such imperfections formation depending on the technological ...
Boris О. Tkachenko, Аnna V. Balaniuk
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Automation of technological preparation of metal working on heavy machine tools [PDF]
, 2018 The programs for selection of the cutting tools construction and cutting regimes are working in unrestricted surroundings elaborate of addition SharpDevelop in language C#.
Klymenko, G. P., Kvashnin, V. V.
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Наноразмерные многослойно-композиционные покрытия для повышения износостойкости и работоспособности твердосплавных концевых фрез [PDF]
, 2014 Предложен способ повышения работоспособности твердосплавных концевых фрез путем нанесения функциональных покрытий, компенсирующих (сглаживающих) циклические термомеханические напряжения, формируемые во время рабочего и холостого ходов инструмента при ...
Бубликов, Ю. И. +3 more
core
SPRK: A Low-Cost Stewart Platform For Motion Study In Surgical Robotics
, 2017 To simulate body organ motion due to breathing, heart beats, or peristaltic movements, we designed a low-cost, miniaturized SPRK (Stewart Platform Research Kit) to translate and rotate phantom tissue.
Goldberg, Ken +3 more
core +1 more source
Selection of design and operational parameters in spindle-holder-tool assemblies for maximum chatter stability by using a new analytical model [PDF]
, 2007 In this paper, using the analytical model developed by the authors, the effects of certain system design and operational parameters on the tool point FRF, thus on the chatter stability are studied.
Budak, Erhan +4 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
On the Cutting of Metals: A Mechanics Viewpoint
, 2020 The mechanics of large-strain deformation in cutting of metals is discussed, primarily from viewpoint of recent developments in in situ analysis of plastic flow and microstructure characterization.
D. Sagapuram +6 more
semanticscholar +1 more source