Results 81 to 90 of about 388,520 (305)

Modelling and mechanical characteristics of PDC cutter-rock interaction by combining mixed fragmentation modes with dynamic rock strength

Petroleum
Polycrystalline diamond compact (PDC) bit is one of the most widely used drill bits for improving the rate of penetration in deep oil and gas well and geothermal well.
Guangjian Dong, Ping Chen, Xudong Wang, Jianhong Fu, Yingxin Yang   +4 more
doaj   +1 more source

Simulation models of vibrations at holes boring factored in the technological system’s variable rigidity

Trudy Odesskogo Politehničeskogo Universiteta, 2014
At elongated holes boring several imperfections can occur, namely, the surface waviness and shape inaccuracies in the axial section. This research purpose is to establish the regularities of such imperfections formation depending on the technological ...
Boris О. Tkachenko, Аnna V. Balaniuk
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Automation of technological preparation of metal working on heavy machine tools [PDF]

, 2018
The programs for selection of the cutting tools construction and cutting regimes are working in unrestricted surroundings elaborate of addition SharpDevelop in language C#.
Klymenko, G. P., Kvashnin, V. V.
core  

Mathematical simulation and optimization of cutting modes in turning of titanium alloy workpieces [PDF]

, 2016
A predictive modeling technique of optimal cutting modes in machining of workpieces made of titanium alloys, different from the well-known ones, is offered.
Afonasov, Aleksey Ivanovich, Bogoljubova (Bogolyubova), Mariya Nikitichna, Kozlov, Victor Nikolayevich, Sumtsova, Olga Vitalievna   +3 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Наноразмерные многослойно-композиционные покрытия для повышения износостойкости и работоспособности твердосплавных концевых фрез [PDF]

, 2014
Предложен способ повышения работоспособности твердосплавных концевых фрез путем нанесения функциональных покрытий, компенсирующих (сглаживающих) циклические термомеханические напряжения, формируемые во время рабочего и холостого ходов инструмента при ...
Бубликов, Ю. И., Верещака, А. А., Верещака, А. С., Оганян, М. Г.   +3 more
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Achieving high quality surface of laminated glass-reinforced plastics during milling

MATEC Web of Conferences, 2018
Milling is one of the most common ways of workpiece machining, but obtaining a high quality surface of laminated composite materials is difficult due to their layered structure, high strength characteristics and low heat conductivity.
Rychkov Daniel, Lobanov Dmitry, Kuznetsov Aleksey   +2 more
doaj   +1 more source

A generalised approach to torsionality maximisation in longitudinal-torsional ultrasonic devices [PDF]

, 2011
A longitudinal-torsional vibration mode has many applications in ultrasonic systems. Obtaining this behaviour could be achieved either by coupling the longitudinal and torsional modes or by degenerating the longitudinal mode, but the results may be ...
Al-Budairi, Hassan, Harkness, Patrick, Lucas, Margaret   +2 more
core