Results 91 to 100 of about 9,483,959 (401)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Fixed-Parameter Tractability of Hedge Cut

12 pages, 1 figure, to appear in SODA ...
Fedor V. Fomin, Petr A. Golovach, Tuukka Korhonen, Daniel Lokshtanov, Saket Saurabh 0001   +4 more
openaire   +2 more sources

The Effect of Selected Technological Parameters of Laser Cutting on the Cut Surface Roughness

Tehnički vjesnik, 2018
The theoretical part of the paper presents some basics of the laser cutting technology and principles. The characteristics of the CO2 laser beam and the parameters entering the laser cutting process are described. The conventionally used material – S235JR steel, method of its laser cutting and the effect of process technological parameters on the cut ...
Meško, Jozef, Zrak, Andrej, Nigrovič, Rastislav, Nikolić, Ružica R.   +3 more
openaire   +5 more sources

Optimisation of cutting parameters for improving energy efficiency in machining process

Robotics Comput. Integr. Manuf., 2019
Reducing the machining energy consumption (MEC) of machine tools for turning operations is significant to promote sustainable manufacturing. It has been approved that selecting optimal cutting (turning) parameters is an effective approach to reduce the ...
Luoke Hu, Renzhong Tang, Wei Cai, Yixiong Feng, Xiang Ma   +4 more
semanticscholar   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Experimentation and Prediction of the Wear of a Cutting Tool in Turning Process [PDF]

Archives of Metallurgy and Materials, 2018
In the present work, the performance of multilayer coated carbide tool was investigated considering the effect of cutting parameters during turning of 34CrMo4 Low alloy steel.
M. Merzoug, N. Benamara, A. Boulenouar, B. Bouchouicha, M. Mazari   +4 more
doaj   +1 more source

Optimization of Cutting Parameters for Trade-off Among Carbon Emissions, Surface Roughness, and Processing Time

Chinese Journal of Mechanical Engineering, 2019
As the manufacturing industry is facing increasingly serious environmental problems, because of which carbon tax policies are being implemented, choosing the optimum cutting parameters during the machining process is crucial for automobile panel dies in ...
Zhipeng Jiang, D. Gao, Yong Lu, Xianli Liu   +3 more
semanticscholar   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Roughness evolution of previously milled samples along a polishing test [PDF]

, 2016
In the present work results about roughness evolution along a polishing operation with corundum disks of size Norton 400 are presented. Hardened steel and hardened stainless steel samples were previously subjected to ball-end milling or side milling with
Buj Corral, Irene, Vivancos Calvet, Joan
core   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source