Results 41 to 50 of about 5,220,601 (292)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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THE USE OF THE HARD METAL TOOLS ON THE BAR TURNING OF THE NYLON [PDF]
Tecnologia em Metalurgia, Materiais e Mineração, 2014 In the market for cutting tools there are not specific tools for machining polymers, where the main difficulty is chip control. Cutting tools are only available for machining metals.
Karen Juliana Vanat +1 more
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Research on Cutting Temperature of GH4169 Turning with Micro-Textured Tools
Applied Sciences, 2023 The GH4169 superalloy has the characteristics of high strength, strong thermal stability, large specific heat capacity, small thermal conductivity, etc., but it is also a typical hard-to-cut material.
Xinmin Feng +3 more
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Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
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Meitan kexue jishu, 2023 Roadheaders play a vital role in enhancing coal mine production efficiency, but they also generate a significant amount of dust during high-intensity cutting.
Wendong ZHOU, Hetang WANG, Leilei SI
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
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PhotonicsPresented in this study is a validated semiempirical model of the effects of femtosecond laser pulse energy on the effective z-position of the resulting cut after laser-induced optical breakdown. Different energy levels (for the same spot spacings, i.e.,
Simas Sobutas, Samuel Arba Mosquera
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
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Laser Cutting of Stainless Steel Thin Sheets with Pulsed Nd:Yag Laser [PDF]
, 2008 The parameters of laser cutting mainly depend on material and from thickness. In case of a given material and thickness many settings can be chosen. In this article we examine the laser cutting of 0,4 mm thickness stainless steel sheets with pulsed Nd ...
Dobránszky, János +2 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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