Results 81 to 90 of about 780,101 (308)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
An experimental study of the effect of high-pressure water jet assisted turning (HPWJAT) on the surface integrity [PDF]
, 2011 This study deals with the effect of High-Pressure Water Jet Assisted Turning (HPWJAT) of austenitic stainless steels on chip shape and residual stresses. The machining of the austenitic stainless steels represents several difficulties. Recently, research
HABAK, Malek, LEBRUN, Jean-Lou
core +4 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Modelling and simulation of the dynamic cutting process and surface topography generation in nano/micro cutting [PDF]
, 2008 In nano/micro cutting process, the surface quality is heavily dependent on all the dynamic factors in machining including those from the material, tooling, cutting parameters, servo accuracy, mechanical structure deformation, and non-linear factors as ...
Cheng, K, Zhou, L
core
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Investigating the Effect of Cutting Condition on the Plastic Energy in Turning Process of AISI 1050 [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2019 Reducing energy consumption is a demanding issue considering the limited available energy resources and increasing environmental pollution. On the other hand, industry consumes a huge amount of energy, and manufacturing processes are the most energy ...
Mohammad Meghdad Fallah +1 more
doaj
Archives of Metallurgy and Materials, 2017 This paper presents the influence of cutting parameters (Depth of cut, feed rate, spindle speed and cutting fluid flow rate) on the surface roughness and flank wear of physical vapor deposition (PVD) Cathodic arc evaporation coated TiAlN tungsten carbide
Moganapriya C. +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source