Results 141 to 150 of about 408,011 (339)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Acceleration of Lagrangian Method for the Vehicle Routing Problem with Time Windows
International Journal of Industrial Engineering and Production Research, 2012 The analytic center cutting plane method (ACCPM) is one of successful methods to solve nondifferentiable optimization problems. In this paper ACCPM is used for the first time in the vehicle routing problem with time windows (VRPTW) to accelerate ...
Hadi Karimi, Abbas Seifi
doaj
Modular coloring formulas are hard for cutting planes proofs [PDF]
, 1996 Xudong Fu
openalex +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Stochastic Dynamic Cutting Plane for Multistage Stochastic Convex Programs [PDF]
, 2021 Vincent Guigues, Renato D. C. Monteiro
openalex +1 more source
A Polynomial Optimization Approach to Constant Rebalanced Portfolio Selection [PDF]
We address the multi-period portfolio optimization problem with the constant rebalancing strategy. This problem is formulated as a polynomial optimization problem (POP) by using a mean-variance criterion.
Sotirov, R., Takano, Y.
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Discussing the Cutting Method of Skew Bevel Bear based on the Tooth Surface Generating Line
Jixie chuandong, 2020 The principle of tooth surface generating of skew bevel gear is analyzed about spherical involute， based on the theory that the line which in the plane that is tangent with the base cone of the skew bevel gear roll on the cone surface absolutely， a new ...
Baichao Wang +4 more
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